Zinc oxide-modi ﬁ ed mordenite as an e ﬀ ective catalyst for the dehydrogenation of (bio)ethanol to acetaldehyde †

The direct transformation of ethanol to acetaldehyde is an important step in the cascade conversion of bioethanol to higher value chemicals and for the development of sustainable fuels. Herein, zinc oxide supported on alkali cation-exchanged mordenite (ZnO/M – MOR) prepared by a simple wetness impregnation method, is shown to be a selective and stable catalyst for the direct dehydrogenation of ethanol to acetaldehyde at 400 (cid:1) C under continuous ﬂ ow conditions. Through variation of the ZnO loading and the zeolite counter-cation (Na, K, Rb, Cs), an optimum catalyst material was identi ﬁ ed, ZnO/ Rb – MOR loaded at 3.5 wt% Zn. Acetaldehyde productivity (normalised to Zn) could be increased by over 80% and ethylene selectivity reduced to 0.9% through simple variation of the extra-framework alkali cation. Very low ethylene production leads to low levels of carbonaceous deposits and therefore minimal deactivation at short time on stream (<5 h). Detailed analysis of the optimized system reveals excellent selectivity and stability beyond 120 h time on stream, resulting in an average acetaldehyde productivity of 16 mmol g cat (cid:3) 1 h (cid:3) 1 and overall acetaldehyde selectivity of 90% whilst operating at an ethanol conversion level of 40%. Additionally, the use of a zeolite support is shown to greatly improving the usage e ﬃ ciency of Zn atoms by virtue of an acetaldehyde productivity increase from 20 to 48 mmol mmol Zn (cid:3) 1 h (cid:3) 1 for unsupported and supported ZnO, respectively. The new catalyst system shows that ZnO can be tuned to give very low ethylene selectivity and extended lifetimes in ethanol dehydrogenation to acetaldehyde which has not previously been reported.


Introduction
Bioethanol, a common biofuel, is currently produced on a large scale (28 billion gallons in 2018) by fermentation of biomass (such as corn and sugarcane) with production predominantly localized in the USA and Brazil. 1 In the USA, bioethanol is produced in excess and added to inventory as demands for fuel blending and exports have already largely been met. 2 The direct transformation of bioethanol into (bio)acetaldehyde and beyond could therefore prove to be a more sustainable route to many higher-value chemicals, one which utilizes an available and renewable carbon feedstock.Further, the direct transformation of bioethanol to acetaldehyde and beyond may be of industrial interest owing to its potential protability. 3Fig. 1 outlines potential routes to higher value products following production of (bio)acetaldehyde from (bio)ethanol, namely the synthesis of n butanol 4 (Guerbet reaction) and butadiene 5 (Lebedev reaction), both via the aldol condensation, 6,7 the synthesis of pyridine via acrolein with addition of ammonia (Chichibabin Fig. 1 Schematic routes to higher value products available following production of (bio)acetaldehyde from (bio)ethanol, such as pentaerythritol ( ), butanol and butadiene ( ) and pyridine ( ).
Partial oxidation is an exothermic process and produces one equivalent of water as a by-product for each acetaldehyde equivalent.Owing to this, whilst lower reaction temperatures are typically utilized, an energy penalty is oen incurred to separate the resultant water from the acetaldehyde product and unconverted ethanol if puried acetaldehyde or feed recycling are desired.One previous industrially practiced ethanol partial oxidation process, the Veba-Chemie process, operated at elevated temperature (500-650 C) and utilized an elemental silver catalyst resulting in acetaldehyde yields of up to 99% at ethanol conversion values of 50-70%, although requiring the use of fractional distillation to purify the product stream. 10,15cademic research into ethanol partial oxidation typically focusses on the use of supported precious metals such as Pt, 16,17 Pd, 18 and especially Au, [19][20][21][22][23][24] at lower operating temperatures of around 200 C.However, supported precious metal catalysts may oen suffer from short lifetimes due to sintering, requiring frequent regeneration. 25Further, precious metal catalysts are oen seen as undesirable owing to their dwindling reserves and long-term unsustainability.
The direct dehydrogenation of ethanol is an endothermic process and is typically conducted at increased reaction temperatures when compared to the partial oxidation process.The reaction, however, produces a stoichiometric amount of hydrogen gas as a desirable and easily separated by-product that can readily be fed into the hydrogen economy, reducing reliance on the steam reforming and water-gas shi reactions for hydrogen production.Additionally, further conversion of acetaldehyde to higher-value products may require the use of hydrogen in subsequent reaction steps that can be "borrowed" from this initial dehydrogenation (such as n butanol by the Guerbet mechanism). 26Due to the co-production of hydrogen, direct dehydrogenation of ethanol was preferred over partial oxidation in the early part of the 20 th century.3][34][35][36] One such example is the direct production of acetaldehyde from ethanol over Fe-exchanged mordenite (Fe-MOR) zeolites prepared by both solution-state and solid-state ion-exchange methods. 36In this report, acetaldehyde was formed with 7-25% selectivity over Fe-MOR materials at reaction temperatures between 200 to 400 C. Notably, an acetaldehyde selectivity of 79% was reported at a reaction temperature of 100 C over an Fe-MOR catalyst prepared by solid-sate ion-exchange, albeit at very low ethanol conversion values (0.72%).Additionally, some d-block metal-free zeolite systems have been realized as ethanol dehydrogenation catalysts. 15,37Specically, the effect of alkaline metal activation on zeolite ultra-stable Y (USY) in the dehydrogenation of ethanol to acetaldehyde has been studied. 15,38Reaction of ethanol at 450 C over USY treated with Na, K, Rb or Cs hydroxide demonstrated that treatment with NaOH was optimal in terms of both ethanol conversion and acetaldehyde selectivity, whilst retaining catalyst crystallinity. 15revious unpublished work within our group has shown that the MOR framework has potential to improve the selectivity to acetaldehyde from ethanol by reducing the range of sideproducts in comparison to MFI and BEA frameworks, under similar reaction conditions.Hence, in this study, we have screened a large library of metal oxide species supported on sodium-form mordenite (Na-MOR) for the direct dehydrogenation of ethanol to acetaldehyde at 400 C. Following the initial screening of metal oxides, ZnO was identied as a promising candidate to be supported on MOR.Although unsupported ZnO has been recognized as an ethanol dehydrogenation catalyst for close to a century, [39][40][41][42] the benets of a tuneable zeolite support are herein shown to be signicant.Hence, we explored the effect of varying the ZnO loading and zeolite counter-cation to arrive at the optimum catalytic material in this study, ZnO/Rb-MOR- (7) with a nominal zinc content of 3.5 wt%.Variation of the zeolite counter-cation is shown to be able to enhance the acetaldehyde productivity (normalised to Zn) and minimise ethylene selectivity.Additionally, ZnO (3.5)/ Rb-MOR- (7) was subjected to a long-term stability test and is shown to give reproducible performance combined with steady acetaldehyde production over 120 hours time on stream (TOS).We believe that such a catalyst may offer a robust and efficient alternative for (bio)acetaldehyde production which utilises a renewable and available carbon source.

Characterisation of materials
Metal loadings were determined by ICP-OES analysis using a Jobin Yvon Horiba Ultima 2 instrument, with the following setup: radial torch, sequential monochromator, cyclonic spray chamber and concentric nebulizer.Zeolite materials were initially subjected to digestion in concentrated hydrouoric acid, allowed to evaporate at 150 C and subsequently redissolved in a known volume of nitric acid in order to perform ICP-OES measurements.Metal loadings determined by ED-XRF spectroscopy were acquired using a Panalytical Epsilon 1 ED-XRF spectrometer.Powder X-ray diffraction (pXRD) diffractograms were collected on a Bruker D8 Advance X-ray diffractometer with Cu Ka radiation (l ¼ 1.54184 A) using a step of 0.02 over a range of 2q ¼ 5-70 .A knife edge was utilized for low angle scattering.pXRD samples were sieved to <177 mm (80 mesh), mounted onto either glass or silicon (9 1 1) slide holders by adhesion with petroleum jelly and rotated during data acquisition.Solid-state 27 Al NMR spectra were acquired on a Varian VNMRS spectrometer operating at 104.198 MHz with a spinning rate of approx.14 kHz.Spectra were obtained using direct excitation with a recycle delay of 0.2 s over 10 000 scans.Spectra were referenced to an external standard of 1 M aq.Al(NO 3 ) 3 solution which was used as a primary reference (d Al ¼ 0 ppm).Scanning Electron Microscopy (SEM) was performed on a FEI Helios Nanolab SEM operated at 5 kV.The zeolite powders were suspended in isopropyl alcohol by ultrasonic treatment for 5 min.Samples were deposited onto a silicon (1 0 0) wafer (Agar Scientic, wafer thickness: 460-530 mm, polished) and coated with 20 nm of gold using a Cressington sputter coater 108 Auto.Scanning electron microscopyenergy dispersive X-ray spectroscopy (SEM-EDS) mapping was performed on a Zeiss Sigma 300 VP SEM operated at 15 kV.The zeolite powders were rst set into epoxy resin before being mechanically ground down by several micrometers and the surfaces diamond polished.Care was taken to ensure that zeolite particles were not released from the resin during the polishing process and the absence of holes was veried by microscope analysis.As the particles were randomly suspended in the resin, the grinding and polishing steps revealed inner areas of the samples.

Catalytic testing under ow conditions
Reactions under ow conditions were performed using a HEL FlowCAT ow reactor feeding ethanol (absolute, 99.8%, Fisher Scientic UK) via an Eldex Optos 1 HPLC pump.All catalysts were prepared for catalysis by rst pressing at 10 tons for 30 s in an Apollo Scientic XRF die equipped with 32 mm KBX-320 pellets using a Specac hydraulic press.The pressed catalysts were then sieved between 40 to 60 mesh (420-250 mm).Catalyst beds were packed into a stainless-steel reactor with a 4 mm internal diameter and consisted of a 1.6 g SiC (technical grade, approx.80 grit, Fisher Scientic UK) pre-bed, followed by 0.300 g of the desired catalyst diluted with 1.4 g SiC and a 2.0 g SiC post-bed.All catalysts were pre-treated rst at 150 C for 1 hour then at 400 C for 30 minutes under owing He or N 2 (40 mL min À1 ) before being adjusted to the desired reaction temperature (200-400 C).The ramping rate for each stage was 10 C min À1 .Once the desired reaction temperature was reached, the system was further purged with He or N 2 for 30 minutes before ethanol ow (0.171-0.330 mmol min À1 ) was started, feeding via the HPLC pump.On-line product analysis was performed by GC-MS-BID (Shimadzu GC-2010 Plus) equipped with BPX90 (SGE Analytical) or RTX-VMS (Thames Restek) columns for mass spectrometry (MS) detection and a ShinCarbon ST (Thames Restek) column for barrier ionization discharge (BID) detection, further details are contained within the ESI.† In all cases, time on stream (TOS) is dened as the time since ethanol ow commenced.Ethanol conversion, carbon balance, selectivity, yield and effluent composition were calculated as shown in the ESI † using mmol min À1 of carbon as input values.A list of quantitatively calibrated compounds that were factored into calculation for each GC column is additionally provided in the ESI.† It is noted that an oscillatory and lower than expected carbon balance is reported in some experiments and is discussed in the ESI.†

Screening of a library of metal oxide species supported on Na-MOR-(7)
A library of metal oxide impregnated mordenite materials, M x O y / Na-MOR- (7), were prepared by a wetness impregnation method with a targeted metal loading of 3.0 wt% by metal atom.Resultant elemental compositions of the materials, as measured by ICP-OES, can be seen in Table S1.† The M x O y /Na-MOR-( 7) materials were screened for ethanol conversion to acetaldehyde under continuous ow conditions at 400 C. Acetaldehyde productivities normalized by catalyst mass (Fig. 2) and molar metal content (Fig. S2 †) both show ZnO/Na-MOR-( 7) to be superior in terms of acetaldehyde productivity to all other supported metal oxide species tested under these reaction conditions.ZnO/Na-MOR-( 7) produced acetaldehyde as the major reaction product with ethylene as a minor product alongside low-intensity traces of diethyl ether and 1,3-butadiene.Most of the other metal oxide species predominantly produced ethylene as the major product as a result of preferential ethanol dehydration (Table S2 †).The major products produced from ethanol conversion over NiO/Na-MOR- (7) and PdO/Na-MOR- (7) were CH 4 and CO suggesting that acetaldehyde was formed initially but subsequently underwent rapid decarbonylation by the catalysts, a reaction observed for several homogenous Ni and Pd catalysts, 43,44 alongside supported Pd clusters. 27At TOS <0.5 h an induction period in acetaldehyde productivity is observed for some of the catalysts (ZnO/Na-MOR- (7), Co 3 O 4 /Na-MOR- (7) and Fe 2 O 3 /Na-MOR-( 7)), during which period ethylene is the major product (Table S2 and Fig. S3 †).

Stability of the ZnO/Na-MOR-(7) system
Following identication of ZnO/Na-MOR-( 7) as a promising candidate for ethanol dehydrogenation, several further investigations were undertaken into long-term catalyst stability and the effect of varying ZnO loading.Initially, reaction of ethanol over ZnO/Na-MOR-( 7) was monitored over a period of 24 h TOS at an ethanol ow rate of 0.171 mmol min À1 .As shown in Fig. 3, ethanol conversion and carbon balance remain relatively constant at $50% and $70% respectively throughout the 24 hour runtime, implicating the longer-term stability of the catalyst.Additionally, it is observed that whilst the yield of acetaldehyde remains steady with increasing time on stream (23%), the yield of ethylene is seen to decrease rapidly and substantially from around 15% to 3%.Plotting the productivities of acetaldehyde and ethylene over time (Fig. 4) conrms this observation to be ascribed to a substantial and rapid decrease in ethylene productivity whilst acetaldehyde productivity remains constant.The cause of this decrease in ethylene productivity and resultant induction period is currently under investigation but is predicted to be the result of deactivation of an acidic or basic site inherent to either the zeolite material or ZnO particles.Low-intensity traces of diethyl ether and 1,3butadiene were also observed in the product effluent.Hydrogen resulting from direct dehydrogenation was also detected (Fig. S1 †), but not quantied.
As production of anhydrous (99.8%) ethanol by azeotropic distillation is an energy intensive process, it is more desirable to feed ethanol of a lower grade in order to avoid this inefficient  process.In order to assess the ability of ZnO/Na-MOR-( 7) to operate with more dilute, aqueous ethanol feeds, compositions of 95% and 50% ethanol were also fed over the catalyst at 400 C. In each case, the liquid ow rate was kept constant (0.01 mL min À1 ) which resulted in ethanol molar ow rates of 0.171 mmol min À1 , 0.162 mmol min À1 and 0.086 mmol min À1 for anhydrous (99.8%), 95% and 50% compositions respectively.Fig. S4 † shows the acetaldehyde productivity and ethanol conversion of ZnO/Na-MOR- (7) for each feed composition.Therein it is observed that the highest acetaldehyde productivity (8.0 mmol g cat À1 h À1 ) is observed when 95% ethanol is fed over the catalyst.Additionally, previous literature investigation of the effect of water on ethanol conversion over ZnO supports this observation, suggesting a higher extent of inhibition for ethanol dehydration in comparison to dehydrogenation. 40This is a signicant benet as 95% ethanol is a typical composition obtained following traditional fractional distillation of bioderived ethanol and does not require the use of azeotropic distillation with entraining agents such as benzene. 453.Effect of varying the ZnO loading of ZnO/Na-MOR-( 7) on acetaldehyde selectivity Having identied ZnO/Na-MOR-(7) as a stable and productive catalyst, optimisation of the system was undertaken with a priority of increasing acetaldehyde selectivity.During optimisation, the ow rate of ethanol during reactions was increased from 0.171 to 0.330 mmol min À1 to achieve a higher gas hourly space velocity (GHSV) and further differentiate catalyst performance at lower ethanol conversion levels.Initially, the effect of varying ZnO loading on catalytic performance was investigated.ZnO/Na-MOR-(7) catalysts were prepared by wetness impregnation with a targeted loading of 1.0, 3.5, 5.0 and 10 wt% by Zn.
Elemental compositions of catalysts are detailed in Table 1, with further elemental details shown in Table S3.† In order to conrm framework retention, pXRD analysis of the variously loaded ZnO/ Na-MOR-( 7) materials was undertaken.As can be seen in Fig. 5A, all samples successfully retain a MOR framework type following the impregnation and calcination treatment.Additionally, it is observed that the sample loaded to 10.0 wt% Zn exhibits pXRD reections concordant with ZnO, suggesting ZnO clusters of sufficient size to produce a pXRD response are present within this material.Fig. 5B shows the solid-state 27 Al NMR spectra of each ZnO/Na-MOR-( 7) material and conrms that aluminium exists solely in tetrahedral framework positions (d Al z 60 ppm) therefore ruling out any effect of extra-framework alumina on catalysis. 46Further, SEM imaging of the four catalyst variations did not show evidence of any change in catalyst morphology or large ZnO clusters on the surface of the catalyst crystals (Fig. 5C).In order to further assess Zn distribution within the materials, a sample of each material was set into resin before being mechanically ground down and diamond polished and subject to SEM-EDS analysis.This preparation resulted in exposure of the crystal interiors and allowed assessment of elemental distribution within the zeolite crystals.Elemental mapping of Zn within the prepared samples showed a largely homogenous distribution throughout the newly exposed surfaces of the materials with few ZnO nanoparticles present.Those ZnO particles which were present were largest and more frequently observed for samples with higher Zn loadings (Fig. S5-S8 †).The prepared catalysts were each tested for ethanol dehydrogenation to acetaldehyde at 400 C for 4 h TOS.Fig. 6A shows that a maximum acetaldehyde productivity is observed at 10 wt% ZnO loading, followed by 3.5 wt% Zn loading, when normalized by catalyst mass.The molar productivity of acetaldehyde per mole of ZnO, however, decreases with increased ZnO loading, suggesting that the catalytic efficiency of ZnO clusters decreases with increasing ZnO loading (Fig. 6B).This is most likely resultant from the increasing size and frequency of large ZnO clusters in higher loaded samples leading to proportionally fewer available active sites.Fig. 6D shows that ethylene selectivity decreases with increasing ZnO loading.Combined, these effects lead to the observation of a maximum acetaldehyde selectivity for ZnO/Na-MOR-( 7)-10%, with ZnO/ Na-MOR-(7)-3.5% performing at near identical levels (Fig. 6C).Overall, these observations show ZnO/Na-MOR-(7)-3.5% to be optimal, balancing lower metal loading and high molar productivity with low ethylene selectivity.All catalysts maintained an ethanol conversion value of around 30-50% (Fig. S9A †) at an ethanol ow rate of 0.330 mmol min À1 .Additionally, a carbon balance of 80+% was observed for all reactions (Fig. S9B †).The yield of acetaldehyde was observed to be highest for ZnO/Na-MOR-(7)-3.5% and ZnO/Na-MOR-(7)-10.0%(Fig. S9C †).Further, elemental microanalysis of the spent catalyst charges showed the nal C wt% value of the materials following reaction decreased with increasing ZnO loading from   S4 †).[49]

Effect of varying zeolite counter-cation on acetaldehyde selectivity
In an attempt to further optimize the performance of zinc oxide impregnated mordenites in ethanol dehydrogenation, the effect of the zeolite counter-cation was investigated.The parent zeolite, Na-MOR- (7), was rst exchanged to completion with metal nitrate solutions of K + , Rb + and Cs + before wetness impregnation with Zn(NO 3 ) 2 $6H 2 O and subsequent calcination to afford ZnO/M-MOR-( 7) with a targeted 3.5 wt% Zn where M ¼ K, Rb, or Cs.Table 2 shows the relevant elemental ratios and compositions for ZnO/M-MOR-( 7) materials; further elemental compositions of the materials obtained by ICP-OES can be seen in Table S5.† Whilst both K + and Rb + were seen to undergo complete ion-exchange, the Cs + level was not seen to rise above 79% despite further and repeated exchange  7) and ZnO/Cs-MOR- (7).It is noted that, whilst reduced crystallinity of ZnO/Rb-MOR- (7) and ZnO/ Cs-MOR-( 7) cannot be ruled out, changing zeolite counter cations may have an effect on pXRD peak intensities as they are strongly determined by the electron density distribution within the zeolite unit cell.Previous publications suggest that low angle reections are the ones most strongly affected by nonframework species in zeolites 55,56 and similar observations have also been reported in the literature. 57,58g. 8 shows relevant productivity and selectivity data during the conversion of ethanol to acetaldehyde over ZnO/M-MOR-( 7) (M ¼ Na, K, Rb, or Cs) materials at 400 C for 4 h TOS.It is observed that the zeolite extra-framework cation has a signicant effect on acetaldehyde productivity, with a general improvement in performance as follows: Rb + > Cs + > K + > Na + .It is noted, however, that the incomplete exchange of Cs + ions may have resulted in lower activity than if complete exchange were achieved for ZnO/Cs-MOR- (7).Fig. 8A and B show that ZnO/Rb-MOR-( 7) exhibits superior acetaldehyde productivity when normalized by both mass and ZnO molar content with average values of approximately 27 mmol g cat À1 h À1 and 67 mmol mmol ZnO À1 h À1 respectively.Additionally, the selectivity to ethylene, a major side product originating from ethanol dehydration is observed to be lowest for ZnO/Rb-MOR-( 7) at approximately 1% (Fig. 8D).As a result, the selectivity to acetaldehyde for ZnO/Rb-MOR-( 7) is shown to be superior to the other tested materials with acetaldehyde accounting for around 95% of detected carbon containing products (Fig. 8C).Ethanol conversion for all reactions was around 30-50% at an ethanol ow rate of 0.330 mmol min À1 (Fig. S10A †).The carbon balance for all reactions was maintained at around 90% (on average) for all catalysts (Fig. S10B †).Very small amounts of additional carbon-containing products were detected (CO, CO 2, CH 4 ) but not quantied and therefore the missing carbon balance is partly attributed to these products and visible carbonaceous deposits.Coking values for spent catalysts as determined by CHN microanalysis are given in Table S6, † as previously  2.62 0.00 0.97 0.00 0.00 ZnO/Rb-MOR- (7)  3.12 0.00 0.00 1.00 0.00 ZnO/Cs-MOR- (7)  3.09 0.00 0.00 0.00 0.79 observed for ZnO/Na-MOR-( 7) materials, carbon coking is generally seen to decrease with decreasing ethylene selectivity.ethanol ow rate of 0.300 mmol min À1 .Fig. S11C † shows that the yield of acetaldehyde remains around 25%, with detected minor products including ethylene, ethane and trace amounts of diethyl ether.Fig. S11E † demonstrates that the average carbon balance is maintained above 80% across all replications, consistent with some coke deposition and possibly small contributions from non-calibrated carbon-containing species.Fig. 9 shows cumulative acetaldehyde production and acetaldehyde selectivity following reaction of ethanol at 400 C for 120 h TOS over ZnO (3.5)/Rb-MOR-( 7) at an ethanol ow rate of 0.330 mmol min À1 .Notably, throughout the course of reaction, a selectivity for acetaldehyde is maintained above 90% (Fig. 9B).Following an initial decrease in acetaldehyde productivity (Fig. S12 †), a steady acetaldehyde productivity of around 16 mmol g À1 h À1 is achieved for the remaining 120 h TOS.Crucially, only a low level of deactivation is observed throughout the 120 h TOS, suggesting a long and stable catalyst lifetime.Additionally, Fig. S13 † demonstrates that an initial ethanol conversion of 40% and acetaldehyde yield of 25% are achieved with minor deactivation observed towards 120 h TOS.A carbon balance of around 90% was maintained throughout the course of the reaction.
In order to assess catalyst condition following reaction with ethanol for 120 h TOS, pXRD analysis, 27 Al solid-state NMR spectroscopy and CHN microanalysis were undertaken.Fig. S14 † shows the resulting pXRD diffractograms (A) and solid-state 27 Al spectra (B) for the fresh and spent catalysts indicating retention of both a MOR type framework and aluminium atoms exclusively in tetrahedral framework positions.Following reaction, the spent catalyst charge was found to possess a carbon content of 4.67 wt% by CHN microanalysis, very similar to 4 h TOS (3.52 wt%) (Table S7 †).Fig. S15 † demonstrates that ethylene productivity decreases signicantly from 0.73 mmol g À1 h À1 within the rst two hours of reaction before levelling off to around 0.2 mmol g À1 h À1 for the remaining reaction duration.This observation adds further credibility to the hypothesis that ethylene productivity (and subsequent aromatisation) is almost solely responsible for coke deposition within this system and typically occurs within the initial two hours of reaction.We propose that through catalyst optimisation, ethylene productivity has become negligible, and deactivation through the formation of carbonaceous deposits is minimised, leading to the extended catalyst lifetime observed.Further, we predict that catalyst activity may extend signicantly beyond 120 h TOS, therefore further increasing industrial applicability.

Effect of zeolite support on acetaldehyde productivity
Unsupported ZnO has been previously reported in the existing literature to be an efficient catalyst for the dehydrogenation of ethanol, [39][40][41][42] typically achieving acetaldehyde selectivities of around 70% in a temperature range of 350-400 C. 40,59 The major side product of ethanol reaction over ZnO is reported to be ethylene (approximately 20-30%) with minor traces of acetone and other oxidation products.Varying catalyst pretreatment between oxidative and inert conditions, and at different temperatures, has been shown to result in differing ethylene selectivities (38-28%) indicating the importance of the surface properties of the catalyst to the performance. 59In addition to this nding, Morales et al. have reported very high acetaldehyde selectivities (88-94%) and low ethylene selectivities (1-7%) at 350 C (6 h TOS) for a series of synthetic ZnO materials where the morphological properties of the resultant crystalline material varied, exposing different ZnO facets to different degrees. 60In addition, ZnO supported on silica (ZnO/ SiO 2 , 0.5 Zn wt%) has been shown to give 7.5% ethylene selectivity whilst achieving 62% acetaldehyde selectivity at 360 C (10 h TOS). 61Some of the data reported in the preceding publications is given in Table S7.† It is clear that due to the differing test conditions, direct comparison is challenging.However, none of the aforementioned materials were tested beyond 10 h TOS and therefore long-term performance has not been established.In addition, whilst the data reported by Morales et al. show very good selectivities, the materials give lower calculated acetaldehyde productivities per unit zinc than those previously described in this contribution (e.g.22.3 mmol mmol Zn À1 h À1 for sample ZnO-E3) showing that supporting ZnO on mordenite results in better productivity and better selectivity than the materials reported by Morales et al. 60 The role of the newly introduced zeolite support, Rb-MOR, was assessed in-house by means of comparison between supported and unsupported ZnO alongside a physical mixture of ZnO and the zeolite support.In this investigation, the molar Zn content of each catalyst was kept constant as shown in Table 3. Fig. 10 shows the selectivities to major products at 0.2 h (A) and 4.0 h (B) TOS for ZnO/Rb-MOR- (7), ZnO and a physical mixture of ZnO and Rb-MOR- (7).Acetaldehyde productivity per unit Zn and ethanol conversion levels are shown in Fig. 10C and  D. Fig. 10B demonstrates that each catalyst achieves similar acetaldehyde selectivities of over 80% aer 4 h TOS with supported ZnO/Rb-MOR-( 7) achieving the highest selectivity of 89%.Fig. 10C, however, shows the signicant effect of the zeolite support in increasing acetaldehyde productivity per unit Zn.As would be expected, both unsupported ZnO (12.6 mg) and physically mixed ZnO + Rb-MOR-( 7) achieve similar acetaldehyde productivities of around 20 mmol mmol Zn À1 h À1 , similar to that reported by Morales et al. 60 Supported ZnO/Rb-MOR-( 7), however, is able to achieve an acetaldehyde productivity of around 48 mmol mm Zn À1 h À1 marking nearly a 150% increase of productivity per unit Zn when compared to the unsupported materials.This increased acetaldehyde productivity is most likely attributed to improved Zn dispersion (as discussed in Section 3.3) and a resultant higher availability of active sites.The increased productivity is also due to an almost doubled ethanol conversion of around 35-40% for ZnO/Rb-MOR- (7) in comparison to around 20-25% for ZnO (12.6 mg) and ZnO + Rb-MOR- (7).In all cases, carbon balance was maintained above 80% (Fig. S16 †).This result is signicant as it suggests that, when correctly modied, zeolite supports are able to improve the catalytic efficiency of metal oxide materials hence allowing more effective use of diminishing metal reserves.Although zinc is not commonly regarded as a physically scarce metal, its supplies are predicted to decline within the coming century with a resultant increase in price and decrease in quality as likely outcomes. 62Hence, awareness of how to best utilise Zn in the most sustainable manner is important, especially if applied to potential large scale industrial processes, such as the transformation of (bio)ethanol to acetaldehyde.The origin of the enhanced productivity of ZnO  supported on mordenite, as well as understanding the striking inuence of the extra-framework cation, will be investigated further.

Comparison to state of the art systems
In all, we have shown that ZnO (3.5)/Rb-MOR- (7) presents several advantages in comparison to other contemporary systems reported for the production of acetaldehyde from ethanol in the current literature.Primarily, ZnO (3.5)/Rb-MOR-( 7) is recognised as a true direct dehydrogenation catalyst owing to the lack of O 2 co-feed required in order to produce acetaldehyde.In this regard, whilst operating at 673 K, ZnO (3.5)/Rb-MOR-( 7) was able to achieve a 25% acetaldehyde yield based upon carbon fed (Fig. S13 †) in comparison to the 10-15% yield reported for NaUSY-0.1 at the same temperature. 15As a result of O 2 independence, it is highlighted that reaction of ethanol over ZnO (3.5)/Rb-MOR- (7) additionally results in formation of hydrogen as an added-value by-product.Further, ZnO (3.5)/Rb-MOR-( 7) possesses a long catalyst lifetime with a low level of observed deactivation following 120 h TOS.From our analysis, we conclude that these observations are resultant from a largely homogenous distribution of ZnO nanoparticles distributed within the zeolite micropore network that are resistant to sintering and other forms of deactivation.This long lifetime presents a considerable improvement in comparison to many contemporary catalysts that use Cu as a dehydrogenation catalyst which suffer from signicant deactivation as a result of sintering within as little as 2 h TOS. 63Other supported Cu systems, such as Cu-ZnAl 2 O 4 also suffer from deactivation, although at slightly extended timescales (5-10 h). 64It must be noted, however, that some modern preparation methods may lead to Cu based systems with comparable stabilities to ZnO (3.5)/Rb-MOR- (7) reported herein, e.g. a Cu-BEA with a stable lifetime of 100 h, 32 and a highly dispersed Cu/SiO 2 prepared by ammonia evaporation with a lifetime of 500 h. 65Additionally, copper on calcium silicate catalysts have been reported to exhibit a remarkably stable acetaldehyde production, however the longest recorded reaction duration was 20 h. 66Finally, ZnO (3.5)/Rb-MOR-(7) may present a desirable alternative to commercial copper chromite catalysts (e.g.BASF Cu-1234-1/16-3F 67 and BASF 0203T 66 ) for the synthesis of acetaldehyde from ethanol.The desire to switch from chromium containing catalysts is due to growing concern that, although active copper chromite catalysts contain Cr 3+ , their production and disposal on an industrial scale may risk production of toxic Cr 6+ . 66

Conclusions
In conclusion, we have shown that ZnO impregnated MOR materials are efficient and selective catalysts for the direct dehydrogenation reaction of ethanol to form acetaldehyde at 400 C under continuous ow conditions.ZnO/MOR catalysts may be optimized by increased ZnO loading and exchange of alkali counter-cation, with ZnO/Rb-MOR-(7) loaded at 3.5 wt% Zn being identied as the optimum catalyst material under the experimental conditions.Signicantly, two key catalytic parameters showed a striking dependence on the alkali extraframework cation of the mordenite zeolite.Acetaldehyde productivity (per unit zinc) was shown to nearly double and ethylene selectivity decreased from 9 to 0.9% (at 4 h TOS) on changing the extra-framework cation from Na to Rb. ZnO (3.5)/ Rb-MOR-( 7) is also shown to possess a long and desirable catalyst lifetime of 120+ h when operating at 40% ethanol conversion, resulting in an acetaldehyde selectivity of 90% and an initial acetaldehyde yield of 25%.Further, the use of a zeolite support is shown to greatly improve the usage efficiency of Zn atoms by virtue of an acetaldehyde productivity increase from 20 to 48 mmol mmol Zn À1 h À1 for unsupported and supported ZnO, respectively.The combination of very low ethylene selectivity, high acetaldehyde selectivity and long catalyst lifetime is commercially desirable and, combined with facile and scalable catalyst preparation, makes ZnO/MOR materials interesting candidates for sustainable fuels and chemicals production from (bio)ethanol.

Table 2
Relevant elemental ratios and compositions for ZnO/M-MOR-(7) materials obtained by ICP-OES where M ¼ Na, K, Rb, or Cs.

Table 3
Molar Zn contents for ZnO/Rb-MOR-(7), a physical mixture of ZnO and Rb-MOR-(7)and ZnO.Zn content for ZnO/Rb-MOR-(7) was determined by ED-XRF with values averaged over three repeat measurements