Issue 5, 2021

A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates

Abstract

We describe here a supramolecular sensing system for the array-based classification of biologically relevant mono-, di-, and tri-phosphates in aqueous buffer. The system is based on a colorimetric indicator displacement assay (IDA) with six sensor elements. Each sensor element is comprised of an equimolar cyclic peptide-colorimetric indicator ensemble. Correct classification of the eleven analytes into mono-, di-, tri-, or pyrophosphate was achieved through both principal component analysis (PCA) and linear discriminant analysis (LDA).

Graphical abstract: A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates

Supplementary files

Article information

Article type
Paper
Submitted
02 Dec 2020
Accepted
18 Dec 2020
First published
21 Dec 2020

Org. Biomol. Chem., 2021,19, 1017-1021

A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates

V. E. Zwicker, G. E. Sergeant, E. J. New and K. A. Jolliffe, Org. Biomol. Chem., 2021, 19, 1017 DOI: 10.1039/D0OB02397C

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