NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia

Fengmin Yang; Qian Li; Junfeng Xiang; Hong Zhang; Hongxia Sun; Guorui Ruan; Yalin Tang

doi:10.1039/D0MO00067A

NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia†

Fengmin Yang,^ab Qian Li,^a Junfeng Xiang,^a Hong Zhang,^a Hongxia Sun,*^a Guorui Ruan*^c and Yalin Tang

*^ab

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* Corresponding authors

^a National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
E-mail: hongxsun@iccas.ac.cn, tangyl@iccas.ac.cn

^b University of the Chinese Academy of Sciences, Beijing, P. R. China

^c Peking University People's Hospital and Institute of Hematology, Beijing, P. R. China
E-mail: ruanguorui@pkuph.edu.cn

Abstract

Acute lymphoblastic leukemia (ALL) is one of the common malignant tumors. Compared with childhood ALL, the treatment effect of adult B-cell ALL is less effective and remains a big challenge. In order to explore the pathogenesis of adult B-cell ALL and find new diagnostic biomarkers to develop sensitive diagnostic tools, we investigated the plasma metabolites of adult B-cell ALL by using ¹H NMR (nuclear magnetic resonance) metabolomics. Relative to healthy controls, adult B-cell ALL patients showed abnormal metabolism, including glycolysis, gluconeogenesis, amino acid metabolism, fatty acid metabolism and choline phospholipid metabolism. What's more important, we also found that the optimal combination of choline, tyrosine and unsaturated lipids has the potential to diagnose and prognose adult B-cell ALL in the clinic.

Molecular Omics

NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia†

Abstract

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