Palladium photocatalysis: a strategic approach for visible-light-mediated C(sp2)–H arylation

Abstract

A strategic and energy-efficient protocol has been developed to construct C(sp²)–C(sp²) bonds through C–H bond functionalization. Herein, Pd-photoredox catalysis under blue LED irradiation was used to generate aryl (or heteroaryl) radicals from the corresponding redox-active iodoarenes and utilize them in C–H bond arylation. The key attraction lies in the wide functional group tolerance with impressive yield and the late-stage functionalization of natural products under mild reaction conditions. Operational simplicity and mechanistic evidence for photoinduced Pd catalysis illustrate the promise of this approach as a comprehensive platform for sustainable aryl–aryl cross-coupling.