Electrochemical oxidative Z -selective C(sp 2 )–H chlorination of acrylamides †‡

An electrochemical method for the oxidative Z -selective C(sp 2 )–H chlorination of acrylamides has been developed. This catalyst and organic oxidant free method is applicable across various substituted tertiary acrylamides, and provides access to a broad range of synthetically useful Z - b -chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.

A diverse array of important compounds contain chlorine atoms, including pharmaceuticals, natural products, agrochemicals, and polymers. 1Furthermore, Z-chloroacrylic acid derivatives serve as useful building blocks to selectively access ubiquitous Z-configured olefins. 2 Existing synthetic methods to access Z-b-chloroacrylic acid derivatives include Vilsmeier-Haack, 3 Wittig, 4 and chloropalladation/Heck approaches, 5 in addition to hydrochlorination 6 and carbochlorination 7 of alkynes, which somewhat limits the accessible substitution patterns and some of these methods can exhibit poor E/Z selectivity.As such, the development of new synthetic methods that enable the direct and selective access to Z-chloroacrylic acid derivatives is an important and timely goal in organic synthesis.Recently, Besset and co-workers reported the Pdcatalyzed Z-selective chlorination of secondary acrylamides bearing an 8-aminoquinoline directing group (Scheme 1A), employing N-chlorosuccinimide as the chlorinating agent, representing a state-of-the-art approach. 8rganic electrochemistry presents vast opportunities for the development of efficient and selective synthetic methods. 9A variety of electrochemical methods have been developed for the chlorination of organic compounds, including alkene dichlorination, 10 chlorofunctionalization of alkenes 11 and alkynes, 12 aromatic chlorination, 13 a-chlorination of 1,3-dicarbonyl compounds, 14 and deconstructive chlorination of cycloalkanols. 15As such, we envisaged the development of an electrochemical oxidative Z-selective C(sp 2 )-H chlorination of acrylamides to generate valuable Z-bchloroacrylamides (Scheme 1B), and herein we report the successful realization of this approach.
Scheme 1 State-of-the-art and outline of the electrochemical strategy.Employing a constant cell potential (E cell = 3.75 V) or variation of the current (i = 15 mA or 5 mA) lowered the NMR yield of 2 (entries 3-5), as did substituting the platinum foil cathode for graphite (entry 6).Employing LiCl or NaCl as the chloride source was detrimental to conversion, presumably due to the decreased solubility in MeCN : AcOH (entries 7 and 8).Using MeCN : MeOH (3.5 : 1) as solvent resulted in reduced conversion to 2. Lowering the quantity of MgCl 2 to 3 equivalents reduced the NMR yield of 2 to 68%, which increased to 78% upon the addition of LiClO 4 (2 equiv.)as a supporting electrolyte.A faradaic efficiency of 85% was obtained when 2 F mol À1 of charged was passed (entry 12), which indicated that most of the electricity passing through the cell is utilized productively.Replacing MgCl 2 with MgBr 2 resulted in recovery of 1 (490%).
With optimized reaction conditions in hand (Table 1, entry 1), the full scope and limitations of the electrosynthetic method with respect to the acrylamide starting materials was evaluated (Scheme 2).Unless otherwise stated, only the Zalkene isomer was observed for all substrates.Employing N-methyl-N-tosylacrylamide starting materials (Scheme 2A), it was found that various substituents could be incorporated into the C(2)-aromatic unit, including electron-releasing (e.g., 4-OMe), electron-withdrawing (e.g., 4-CF 3 ) and halogen substituents, with the corresponding Z-b-chloroacrylamides products accessed in good yields (products 3-13).Introducing sterically demanding groups into the acrylamide starting materials did not negatively impact upon product formation, with products 8 and 9 formed in 74% and 83% isolated yields, respectively.The introduction of a C(3)-methyl substituent afforded tetrasubstituted Z-b-chloroacrylamide 14 in 75% isolated yield, 18 whereas the C(2)-aryl group could be replaced with a C(2)methyl substituent to access 15 as the major regioisomer (86 : 14 r.r.).Further variation of the acrylamide starting material revealed that a selection of N-alkyl, N-phenyl, and Nsulfonyl substituents could be incorporated to access products 16-20 in high isolated yields (Scheme 2B).Employing a Weinreb acrylamide substrate produced the corresponding vinyl chloride 21 as a 2 : 1 mixture of Z : E alkene isomers, which was isolated in a combined 61% yield.This lower observed selectivity may be attributed to increased C-N partial doublebond character within the Weinreb amide functionality, resulting in a greater steric effect, in comparison to the twisted amide (c.f., substrate 1). 19N,N-Dialkylacrylamides could be employed as substrates, with Z-b-chloroacrylamides 22 and 23 isolated in 61% and 73% isolated yields, respectively.When N,Ndiphenylacrylamide 24 was subjected to the optimized reaction conditions, oxindole 25 was accessed as the sole product (Scheme 2C), which can be formed via intramolecular trapping of a C-centered radical intermediate with a N-phenyl substituent. 20Substituted methyl acrylate 26 produced a mixture of Z-b-chloroacrylate 27 and dichloro ester 28 in 44% and 32% NMR yields, respectively.The formation of 28 may indicate that it is an intermediate on route to the formation of 27, or that the operative reaction mechanism for methyl acrylate substrate 26 is distinct to the tertiary acrylamide substrates predominantly employed.Secondary acrylamide 29 produced a complex reaction mixture whereas acrylamides 30 and 31 were found to be unreactive, presumably due to radical instability and steric encumbrance, respectively.
To demonstrate product utility, the orthogonal functionalization of Z-b-chloroacrylamide 2 was investigated (Scheme 3A).It was found that the C(sp 2 )-Cl functionality could serve as a coupling partner in a palladium-catalyzed Suzuki crosscoupling with 4-methoxyphenylboronic acid to access arylated alkene 32 in 49% isolated yield.Furthermore, the N-sulfonyl activated twisted amide functionality within 2 was hydrolyzed to give the corresponding carboxylic acid derivative 33 in 72% isolated yield, which can serve as a useful building block for further synthetic elaboration.To demonstrate scalability, the batch process was translated to a flow electrochemical setup (Scheme 3B). 21Employing a syringe pump in combination with commercially available Ammonite8 flow electroreactor (volume = 1 mL, i = 370 mA), 22 4.4 mmol of acrylamide 1 was converted to Z-b-chloroacrylamide 2 in 91% isolated yield (1.40 g) in a single-pass.
To obtain insight into the reaction mechanism, acrylamide 34, containing a C(2)-cyclopropyl substituent, was synthesized and subjected to the optimized electrochemical reaction conditions as a radical clock mechanistic probe (Scheme 4A).It was found that ring-opened dichlorinated acrylamide 35 was obtained as a 1 : 1 mixture or Z : E alkene isomers in 44% NMR yield, signifying the likelihood of radical intermediates within the operative reaction mechanism.Cyclic voltammetry studies indicated that chloride ions (E ox = 1.10 V vs. Fc/Fc + ) should undergo preferential oxidation in the presence of electron-deficient acrylamide 1 (E ox = 1.31V vs. Fc/Fc + ).It was also found that replacing MgCl 2 with N-chlorosuccinimide in the absence of electricity resulted in quantitative recovery of 1.In line with these observations, and previous related investigations, 23 a plausible reaction mechanism would initiate with anodic chloride oxidation to form a chlorine radical, 11d,12b,13c,13d which undergoes regioselective addition to the electron-deficient acrylamide 1 to furnish tertiary C-centered radical 36.Further anodic oxidation would form carbocation 37, with subsequent deprotonation providing access to the observed Z-b-chloroacrylamide 2 (path a).Substitution at C(2) is crucial for reactivity (c.f.Scheme 2C, starting material 30), presumably due to the requirement to stabilize intermediates 36 and 37. Deprotonation of carbocation 37 proceeds via the conformation that minimizes steric repulsion between the chlorine atom and the phenyl ring to afford the Z-isomer as the major product stereoisomer (Scheme 4c).Alternatively, carbocation 37 or radical 36 could be intercepted by a chloride anion (path b) or a chlorine radical (path c), respectively, to form dichlorinated compound 38, which could subsequently generate 2 via loss of HCl.Dichlorinated species such as 38 have not been directly observed using acrylamide substrates, however, we cannot unambiguously rule out their intermediacy.Hydrogen gas is generated via proton reduction at the cathode.
In conclusion, we have developed a new electrochemical method for the oxidative Z-selective C(sp 2 )-H chlorination of acrylamides.The method is applicable across various substituted tertiary acrylamides, accessing a broad range of synthetically useful Z-b-chloroacrylamides (22 examples).The orthogonal derivatization of the products was demonstrated through chemoselective transformations, and the electrochemical process was performed on gram scale in flow.
We would like to thank Cardiff University for studentship funding for James Harnedy and the EPSRC for a standard research grant (EP/R006504/1).

Conflicts of interest
There are no conflicts to declare.

a
Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.E-mail: MorrillLC@cardiff.ac.uk b UK National Crystallographic Service, Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK † Information about the data that underpins the results presented in this article, including how to access them, can be found in the Cardiff University data catalogue at http://doi.org/10.17035/d.2021.0143191217.‡ Electronic supplementary information (ESI) available: Optimization data, experimental procedures, characterization of new compounds and spectral data.CCDC 2104458.For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1cc05824j § These authors contributed equally to this work.

Table 1
Reaction optimization a