Issue 91, 2021

Specific osteogenesis imperfecta-related Gly substitutions in type I collagen induce distinct structural, mechanical, and dynamic characteristics

Abstract

The stiffnesses, β-structures, hydrogen bonds, and vibrational modes of wild-type collagen triple helices are compared with osteogenesis imperfecta-related mutants using integrative structural and dynamic analysis via molecular dynamics simulations and Markov state models. Differences in these characteristics are strongly related to the unwound structural states in the mutated regions that are specific to each mutation.

Graphical abstract: Specific osteogenesis imperfecta-related Gly substitutions in type I collagen induce distinct structural, mechanical, and dynamic characteristics

Supplementary files

Article information

Article type
Communication
Submitted
19 Sep 2021
Accepted
19 Oct 2021
First published
19 Oct 2021

Chem. Commun., 2021,57, 12183-12186

Author version available

Specific osteogenesis imperfecta-related Gly substitutions in type I collagen induce distinct structural, mechanical, and dynamic characteristics

H. Shi, L. Zhao, C. Zhai and J. Yeo, Chem. Commun., 2021, 57, 12183 DOI: 10.1039/D1CC05277B

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