A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo

Ziyin Chai; Diankai Liu; Xiaoyi Li; Yanyan Zhao; Wen Shi; Xiaohua Li; Huimin Ma

doi:10.1039/D1CC01462E

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A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo†

Ziyin Chai,^ab Diankai Liu,^a Xiaoyi Li,^a Yanyan Zhao,^a Wen Shi,

*^ab Xiaohua Li

^a and Huimin Ma

*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: shiwen@iccas.ac.cn, mahm@iccas.ac.cn

^b University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Nitroxyl (HNO) is a promising regulator for cancer therapy. Here, we develop a tumor-targeted near-infrared fluorescent probe for HNO and utilize it in the real-time imaging of HNO release in vivo.

This article is part of the themed collection: 10th Anniversary of the Youth Innovation Promotion Association of the Chinese Academy of Science

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Article information

DOI: https://doi.org/10.1039/D1CC01462E
Article type: Communication
Submitted: 18 Mar 2021
Accepted: 09 Apr 2021
First published: 22 Apr 2021

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Chem. Commun., 2021,57, 5063-5066

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A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo

Z. Chai, D. Liu, X. Li, Y. Zhao, W. Shi, X. Li and H. Ma, Chem. Commun., 2021, 57, 5063 DOI: 10.1039/D1CC01462E

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Chemical Communications

A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo†

Abstract

Supplementary files

Article information

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A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo

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