Issue 18, 2024

Total synthesis of diplofuranone A and diapolic acid A

Abstract

The first and concise syntheses of the anticancer agent diplofuranone A and the fatty acid-derived metabolite diapolic acid A have been demonstrated using easily accessible and commercially available starting materials. The key feature of these syntheses is the efficient diversification of highly stereo- and chemoselectively constructed (E,E)-1,6-dioxo-2,4-dienes using ruthenium catalytic conditions, which enabled straightforward access to diversely substituted bioactive molecules.

Graphical abstract: Total synthesis of diplofuranone A and diapolic acid A

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Article information

Article type
Communication
Submitted
16 Mar 2024
Accepted
09 Apr 2024
First published
16 Apr 2024

Org. Biomol. Chem., 2024,22, 3589-3591

Total synthesis of diplofuranone A and diapolic acid A

D. H. Dethe, V. Kumar and N. C. Beeralingappa, Org. Biomol. Chem., 2024, 22, 3589 DOI: 10.1039/D4OB00433G

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