Issue 32, 2021

3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions

Abstract

Described herein is a quinoxalinone-based photoaffinity probe with caged fluorescence properties. Upon visible blue LED irradiation (λmax 450 nm), this photo-crosslinker is able to covalently capture proteins with concomitant fluorescence labelling. This process enables monitoring applications under “no wash” conditions.

Graphical abstract: 3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions

Supplementary files

Article information

Article type
Communication
Submitted
01 Mar 2021
Accepted
12 Mar 2021
First published
12 Mar 2021

Chem. Commun., 2021,57, 3893-3896

3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions

M. Cauwel, C. Guillou, K. Renault, D. Schapman, M. Bénard, L. Galas, P. Cosette, P. Renard and C. Sabot, Chem. Commun., 2021, 57, 3893 DOI: 10.1039/D1CC01072G

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