A shape changing tandem Rh(CNC) catalyst: preparation of bicyclo[4.2.0]octa-1,5,7-trienes from terminal aryl alkynes

Two catalysts for the price of one: a shape changing rhodium catalyst enables preparation of unusual isobenzenes using a one-pot procedure.


Introduction
In pursuit of more efficient synthetic procedures tandem catalysis has emerged as a powerful approach, enabling complex molecules to be assembled in one pot through a precisely choreographed sequence of catalytic steps, reducing waste and saving time (Fig. 1). 1-3 Contrasting cascade or domino reaction manifolds, tandem catalysis involves orchestration of functionally distinct transformations using a single or multiple catalyst precursor(s) (orthogonal tandem catalysis). 2 The former variation is operationally the simplest and harnesses catalyst productivity most efficiently, however, sequencing multiple operations with high delity using a common catalyst precursor can be a formidable challenge. Whilst such temporal control can be accomplished through deliberate intervention to transform the catalyst in situ aer a suitable time period (assisted tandem catalysis), this solution lacks the practical simplicity of autonomous counterparts (auto-tandem catalysis) that do not require reaction monitoring nor additional experimental operations. 3 As part of our work exploring terminal alkyne coupling reactions promoted by rhodium complexes of NHC-based pincer ligands, 4 we serendipitously discovered that [Rh(CNC-Me)(C 2 H 4 )][BAr F 4 ] (1$C 2 H 4 , Ar F ¼ 3,5-(CF 3 ) 2 C 6 H 3 ) is a highly effective auto-tandem precatalyst for the preparation of bicyclo [4.2.0]octa-1,5,7-trienes from terminal aryl alkynes with high selectivity (2 / 3 / 4, Fig. 1). There are only two literature precedents for isobenzenes of this type, with the most pertinent example involving a single-step nickel(0) catalysed annulation of isolated (electron decient) gem-enynes. 5,6 Despite extensive investigation, the selective head-to-tail coupling of terminal alkynes (2 / 3) invoked in the formation of 4 remains a challenging task for transition metal catalysts and is typically accompanied with mechanistically interconnected E-enynes that are products of head-to-head coupling. 7 We have, however, previously demonstrated that 1$C 2 H 4 is a remarkably regioselective precatalyst for the dimerisation of terminal aryl alkynes (2a, R ¼ 3,5-tBu 2 C 6 H 3 ]Ar 0 ; 2b, R ¼ Ph) into the corresponding gem-enynes (3a and 3b) under mild conditions in dichloromethane solution. 4 Upon switching to more weakly coordinating solvent 1,2-F 2 C 6 H 4 (DFB), 8 catalyst stability and activity are signicantly enhanced with no loss of selectivity, but subsequent metal catalysed conversion into 4 became more apparent. Although metal-catalysed reactions of terminal alkynes have been extensively investigated, 9 to the best of our knowledge, this one-pot reaction sequence is unprecedented: a paucity that we attribute to the orthogonal mechanistic demands of the component steps.
Aer briey overviewing the scope of this unique one-pot reaction, we herein present mechanistic and computational studies that suggest the unique catalytic behaviour of 1 is enabled by the ability of the exible CNC ligand to adopt both mer-and fac-coordination modes. 10 This is a potentially widely applicable concept for tandem catalysis.

Scope of tandem reaction
We have previously shown the homocoupling of 2a catalysed by 1$C 2 H 4 (5 mol%) in dichloromethane proceeds at 25 C with a TOF ¼ 2.5 h À1 and exclusive formation of the corresponding gem-enyne 3a (until conversion reached ca. 90%), which was readily isolated by quenching the reaction at high alkyne conversion with carbon monoxide. 4 We now report the use of DFB as a solvent, which results in an order of magnitude faster homocoupling under otherwise equivalent conditions (TOF ¼ 26 h À1 ). On the considerably shorter time frames associated with these experiments, the ensuing metal-catalysed reaction of 3a into balance tetramer 4a was more readily apparent nearing complete consumption of 2a by 1 H NMR spectroscopy, with the appearance of a characteristic 4H singlet resonance at d 2.87 alongside two new 36H tBu resonances at d 1.03 and 1.11 (Fig. 2). Under these conditions, 4a was obtained in quantitative spectroscopic yield within 4 h. Subsequent isolation and characterisation in solution and the solid state enabled unambiguous assignment of 4a as a bicyclo [4.2.0]octa-1,5,7-triene and motivated us to explore the scope of this unique sequential reaction.
Aer ascertaining the intermediacy of gem-enynes, using in situ experiments monitored by 1 H NMR spectroscopy (see ESI †), a straightforward one-pot protocol was developed for the preparation of a range of 2,5,7,8-tetraarylbicyclo-[4.2.0]octa-1,5,7-trienes (Fig. 3). Analytically pure samples of 4a-g were obtained, with unoptimised yields ranging from 64-94%, and fully characterised. This range of products demonstrates the compatibility of the tandem process for both electron withdrawing and donating groups in the para or meta positions of the aryl alkyne. Attempts at employing the bulky mesityl  substituted alkyne 2h, however, yielded only an 80 : 20 mixture of gem-and E-enyne dimerisation products under these conditions. The tandem reaction also appears to be limited to aryl substituted alkynes, with alkyl alkynes 2i (R ¼ nBu) and 2j (R ¼ tBu) failing to afford the respective bicyclo[4.2.0]octa-1,5,7-trienes, even on prolonged heating at 65 C. Homocoupling of these substrates was nevertheless observed, with the latter notable for proceeding with the slow, but exclusive, formation of E-tBuC^CCHCHtBu at 25 C. Monitoring this reaction in situ using 1 H NMR spectroscopy suggests catalytic turnover is impeded by a signicant degree of product inhibition. Indeed, supporting this assertion the corresponding rhodium E-enyne complex [Rh(CNC-Me)(E-tBuC^CCHCHtBu)] [BAr F 4 ] 5 observed in situ was independently synthesised and fully characterised (see ESI †).

Mechanistic proposal and supporting organometallic chemistry
To reconcile the formation of 4 the auto-tandem scheme outlined in Fig. 4 is hypothesised, which involves asynchronous homocoupling of 2 into 3 followed by annulation of 3 into 4: the latter enabled by the capacity of CNC-Me to shuttle between mer-and fac-coordination modes.
A hydrometallation mechanism, which comprises C-H bond oxidative addition of the terminal alkyne (1/IV / I), selectivity determining 1,2-migratory insertion of the second alkyne into the resulting metal hydride (II / III), and rate determining C-C bond reductive elimination to generate the gem-enyne (III / IV), is proposed for the homocoupling based on literature precedents and our previous interrogation of the 1/2a system. 4,7 Pincer complexes have been shown to be effective catalysts for terminal alkyne coupling reactions and these component steps are fully compatible with mer-coordination of CNC-Me throughout the cycle. 11 Indeed, we have previously shown that terminal alkyne coupling of 2a by an analogue of 1, bearing instead a macrocyclic NHC-based pincer ligand [Rh(CNC-12)(C 2 H 4 )][BAr F 4 ] 6$C 2 H 4 , results exclusively in entrapment of the enyne product within the annulus of the ligand. 4 This outcome is only possible if the NHC-based pincer ligand maintains a mer-coordination mode during the homocoupling.
To help provide further evidence for the hydrometallation mechanism, the reaction between 1$C 2 H 4 and 2-ethynylpyridine was studied in DFB (Fig. 5). Heating at 65 C overnight resulted in exclusive formation of Rh(III) gem-alkenyl alkynyl 7 (cf. III), 4,12 where chelation of the pyridine completes the coordination sphere and encumbers onward reductive elimination. Complex 7 was subsequently isolated from solution in 82% yield and fully characterised, including structural elucidation in the solid state using single crystal X-ray diffraction (1.2Å resolution). Key spectroscopic features of 7 include C 1 symmetry, geminal alkene 1 H resonances at d 5.97 and 6.48, and 13 C resonances at d 98.8 (RhC^C, 1 J RhC ¼ 56 Hz) and 137.0 (RhC(CH 2 ), 1 J RhC ¼ 25 Hz) that display large 103 Rh coupling.
Although the annulation of 3 has little direct precedent, parallels can be drawn with oxidative coupling reactions of internal alkynes, which afford metallacyclopentadienes and, in some cases, thereaer the corresponding cyclobutadiene complexes. 13 In these well-established reactions, cis-parallel coordination of the alkynes is a prerequisite for efficient mixing of the alkyne frontier molecular orbitals, 14 and correspondingly the majority of examples are associated with fac-coordinating ancillary ligands (e.g. cyclopentadienyls) that promote these geometries. On this basis we suggest the annulation of 3 commences with distortion of the catalyst geometry in such a way as to place the CNC-Me ligand in a fac-coordination mode and therefore enable binding of two enynes in a cis-parallel arrangement (IV / V). Subsequent oxidative coupling would then afford metallacyclopentadiene VI, with the alkyne carbon atom bearing the most sterically demanding substituents

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forming the s-bond with the metal centre in accordance with Wakatsuki's rule. 14 A metal promoted conrotatory electrocyclic reaction (VI / VII) and product elimination, involving formal alkylidene dimerisation, is thereaer proposed to afford 4. The latter step is related, by the principle of microscopic reversibility, to the insertion of metals into tetraaminoethylenes for which there is precedent for rhodium(I). 15 An alternative product releasing route, where formation of the four-membered ring of the isobenzene precedes that of the six, through formation of the corresponding cyclobutadiene complex of VI and then electrocyclic reaction, was also considered but ultimately discounted (vide infra).
The key requirement of the annulation conjecture is the ability of the CNC ligand to adopt a fac-coordination mode and this was conrmed by reaction of 1$C 2 H 4 with 1 equivalent of norbornadiene (NBD) in DFB at RT, which resulted in quantitative formation of 8 within 3 h in a sealed tube (Fig. 5, 76% isolated yield). Such behaviour is uncharacteristic for pincer ligands, but some examples can be found in the literature. 16 The formation of 8 was established by NMR spectroscopy and X-ray diffraction. In solution, 8 is notable is for the adoption of time averaged C s symmetry of the pincer and fast rotation of the NBD ligand on the NMR time scale (298 K, 500 MHz), carbene resonances at d 187.4 that show enhanced 1 J RhC coupling compared to 1$C 2 H 4 (51 vs. 40 Hz), and an alkene 13 C signal at d 43.6 ( 1 J RhC ¼ 8 Hz). In the solid state the metal adopts a distorted trigonal bipyramidal geometry (C109-Rh1-C115 ¼ 103.60(10) ), with the appreciably shorter axial Rh-NHC (2.026(2) vs. 2.118(3)Å) and equatorial Rh-alkene (1.964(2) vs. 2.144(2)Å) contacts in line with a structurally related complexes. 17 Reaction of isolated 8 with carbon monoxide (1 atm) generated the known square planar carbonyl derivative of 1 within 5 h at RT. 4 Macrocyclic 6$C 2 H 4 also reacts reversibly with NBD and, in strong support of the underlying hypotheses, catalyses the formation of 4a from 3a, albeit under considerably more forcing reaction conditions than its acyclic congener (TON ¼ 2, aer 45 days at 50 C; details provided in the ESI †).
We next turned to probe the capacity for 1 to promote the oxidative coupling of two alkynes, for which di (3-phenylprop-2ynyl)ether was identied from the literature. 18 Gratifyingly, reaction between 1$C 2 H 4 and the propargyl ether in DFB at RT afforded ve-coordinate metallacyclopentadiene 9 within 30 min, as marked visually by its characteristic dark green colour (Fig. 5). Complex 9 was subsequently isolated in 97% yield and fully characterised. In solution 9 displays time averaged C 2 symmetry (298 K, 500 MHz), with the metallacyclopentadiene 13 C resonances located at d 150.8 (RhC(Ph)C, 1 J RhC ¼ 41 Hz) and 155.5 (RhC(Ph)C, 2 J RhC ¼ 3 Hz). Five-coordinate 9 adopts a distorted square pyramidal structure in the solid state, with the pincer ligand in the expected mer-coordination mode. We have previously reported a 2,2 0 -biphenyl complex of 6, which shows a similar geometry and the metal-based metrics are in good agreement. 19 As a structural analogue of VI, we sought to ascertain if the corresponding cyclobutadiene complex could be obtained. As no reaction was evident on extended thermolysis of 9 in DFB (85 C, 24 h) we discount this possibility.

Computational evaluation
To substantiate the proposed auto-tandem reaction and help elucidate the mechanistic intricacies, DFT calculations at the B3PW91-D3/SDD/6-31G** level of theory were employed for the most computationally amenable phenyl-substituted system (Fig. 6). Coordination and C(sp)-H bond oxidative addition of 2b proceeds with a low barrier, but endergonic isomerisation (DG ¼ +7.0 kcal mol À1 ) of the resulting alkynyl hydride I is required to bind the second equivalent trans to the alkynyl (II). 20 The two possible regioisomers of II are nearly isoenergetic, but it is only for the head-to-tail conguration that 1,2-migratory insertion is productive with respect to dissociation. As the reaction thereaer proceeds thermodynamically downhill, this step is irreversible and selectively determining (DDG ‡ ¼ À2.5 kcal mol À1 ). 21 Consistent with the experimental ndings, gem-alkenyl alkynyl III is calculated to be the resting state. Subsequent reductive elimination affording IV is turnover limiting (DG ‡ ¼ 22.0 kcal mol À1 ) and completes the production of 3b, which is formed in DG ¼ À36.6 kcal mol À1 overall.
Two pathways for the annulation have been computationally evaluated: the lowest energy route commences with ring ipping of one of the bridging methylene groups of the pincer backbone, 22 which distorts the metal coordination geometry and ultimately causes CNC-Me to adopt a fac-coordination mode (IV 0 ). This process is associated with a small thermodynamic penalty of DG ¼ +11.6 kcal mol À1 , but appreciable barrier of DG ‡ ¼ 22.8 kcal mol À1 . The latter is consistent with the highly asynchronous nature of the tandem reaction, with the homocoupling proceeding with a lower barrier of DG ‡ ¼ 17.7 kcal mol À1 with respect to IV. The fac-conguration is stabilised by coordination of an additional equivalent of 3b, forming V 0 and from which facile and irreversible oxidative coupling is possible: DG ‡ ¼ 21.7 kcal mol À1 relative to IV, but only 12.1 kcal mol À1 with respect to V 0 . Formation of a cyclobutadiene complex from the resulting fac-metallacyclopentadiene VI 0 was examined, but the associated barrier is considerably higher than formation of the corresponding and thermodynamically preferred mer-isomer VI (DG ¼ À42.1 kcal mol À1 ). The alternative higher energy annulation pathway involves retention of CNC-Me in a mer-coordination mode and converges at VI, but is associated with a prohibitively high activation barrier of DG ‡ ¼ 43.5 kcal mol À1 for the oxidative coupling and is consequently discounted. In line with the experimentally established stability of 9, subsequent C-C bond reductive elimination from VI is prohibitively high in energy (DG ‡ ¼ 55.3/80.2 kcal mol À1 ), however the postulated conrotatory electrocyclic reaction (VI / VII) and alkylidene dimerisation (VII / IV) appears energetically feasible. The latter is predicted to be turnover limiting in the case of the phenyl-substituted system (DG ‡ ¼ +31.4 kcal mol À1 ), producing 4b in DG ¼ À58.0 kcal mol À1 overall. 23

Conclusions
An atom efficient and operationally simple procedure for the synthesis of unusual bicyclic isobenzenes from terminal alkynes is reported. Using this one-pot protocol seven novel tetraaryl-substituted bicyclo[4.2.0]octa-1,5,7-trienes were successfully prepared, with the aryl substituents bearing a range of electron withdrawing and donating groups in the para or meta positions. This synthesis proceeds by a reaction sequence involving head-to-tail homocoupling of the terminal alkyne and annulation of the resulting gem-enyne. Both are catalysed with remarkably high delity by a common rhodium(I) catalyst, which features a exible NHC-based pincer ligand that is hypothesised to interconvert between mer-and fac-coordination modes to full the orthogonal mechanistic demands of the two transformations. Experimental evidence for this interesting auto-tandem action of the catalyst is provided by reactions of the precatalyst with model substrates, corroborating the formation of gem-alkenyl alkynyl and metallacyclopentadiene intermediates in the homocoupling and annulation steps respectively, and norbornadiene, which reversibly captures the change in the pincer ligand coordination mode. This work is supplemented by a detailed DFT-based computational analysis, which supports a hydrometallation-based homocoupling and a zipper-type annulation reaction that proceeds by oxidative coupling of the two gem-enynes, metal promoted conrotatory electrocyclic reaction and a product releasing formal alkylidene dimerisation.
The capacity of the NHC-based pincer ligand to adopt both mer-and fac-coordination modes appears to be central to the success of this one-pot procedure and this concept may prove to be a fruitful for the design of new tandem catalytic reactions.

Conflicts of interest
There are no conicts to declare.