A nickel-catalyzed tandem reaction involving cyclic esterification/C–S bond formation for synthesizing 5-oxa-11-thia-benzofluoren-6-ones

A nickel-catalyzed tandem reaction involving cyclic esterification/C–S bond formation has been developed. Starting from samples containing 3-(2-hydroxy-phenyl)-acrylic acids with 2-halide-benzenethiols, versatile biologically active 5-oxa-11-thia-benzofluoren-6-one compounds were efficiently synthesized in good to high yields. This new methodology provides an economical approach toward C–S bond formation.

Sulfur-containing organic compounds have been widely applied in syntheses of pharmaceutical and functional materials. 1 Due to its relatively large atomic radius and high electron density, sulfur displays relatively high reactivity and is easy to modify, at least in theory. 2 In recent decades, the activation of the C-H bond is considered as one of the most useful C-S bond formation strategies (Scheme 1a). However, compared to C-X (X ¼ I, Br, Cl) cross-coupling, direct C-S bond cross-coupling reactions require harsher conditions and more activated reaction systems (Scheme 1b). 3 Given the present challenges, the development of more efficient and environmentally friendly chemical processes for drug discovery is required. 4 5-Oxa-11-thia-benzouoren-6-one constitutes the central core unit of a variety of natural polycyclic lactones with important biological activities, including anticancer, antibacterial, antimyotoxic, and phytoalexin effects. 5 A wide range of biological properties make 5-oxa-11-thia-benzouoren-6-ones interesting synthetic targets for chemists. Several synthetic Scheme 1 C-S bond formation synthesis approaches.

Scheme 2
The nickel-catalyzed tandem reaction for cyclic esterification/C-S bond formation. Most of the reported procedures involve multiple steps with moderate overall yields. The starting materials are oen not very readily available. And harsh reaction conditions are usually required. In view of these limitations, the development of an efficient strategy for synthesizing 5-oxa-11-thia-benzouoren-6-ones is highly desirable. Herein, we report a novel nickel-catalyzed tandem reaction involving cyclic esterication/C-S bond formation (Scheme 2). Versatile biologically active 5-oxa-11-thia-benzouoren-6-one compounds were efficiently synthesized in good to high yields under mild conditions. This new methodology was concluded to provide an economical approach toward C-S bond formation.
At rst, the reaction conditions were screened based on the model reaction of 3-(2-hydroxy-phenyl)-acrylic acid 1a with 2iodo-benzenethiol 2a ( Table 1). The structure of 3a was conrmed from 1 H NMR, 13 C NMR, and HRMS analyses. Various nickel-containing catalysts were tested, and displayed good catalytic activities in the presence of Na 2 CO 3 (entries 1-7), with the Ni(CO) 4 catalyst exhibiting the best catalytic efficiency (entry 7). Various bases were also tested, and NaOEt was found to be the optimal base (entry 12), having produced the product 3a with an 83% yield. Better results were also obtained when using a 1 : 1.2 ratio of 1a to 2a than when using a 1 : 1 ratio (entries 10 and 12). Also, under these optimized conditions, the product yield was better when the reaction temperature was 90 C than when it was 80 C or 100 C (entries 12, 13 and 14). Furthermore, the results also showed that the reaction yield was higher when using DMSO as the solvent than when using CHCl 3 or DMF as the solvent (entries 12, 15 and 16). Thus, the optimum reaction condition was determined to be that involving reacting 1a and 2a in a 1 : 1.2 ratio in the presence of Ni(CO) 4 (10 mol%) and NaOEt (2 equiv.) in DMSO (5 mL) at 90 C for 10 hours (Table 1, entry 12).

Conclusions
In summary, we have reported a nickel-catalyzed tandem reaction involving cyclic esterication/C-S bond formation. Starting from samples of 3-(2-hydroxy-phenyl)-acrylic acids with 2-halide-benzenethiols, versatile biologically active 5-oxa-11thia-benzouoren-6-one compounds were efficiently synthesized in good to high yields. This new methodology provides an economical approach toward C-S bond formation.

Conflicts of interest
There are no conicts to declare.