From the journal:

Chemical Communications

Excimer-to-monomer switching in a pyrene HOF for discriminative neurotransmitter sensing

Wei Zhang,a   Ziyao Zhang,a   Gongxun Bai,a   Shiqing Xu,a   Hui Xu*a  and  Junkuo Gao ORCID logo *b  

* Corresponding authors

a Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, Institute of Optoelectronic Materials and Devices, College of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, People's Republic of China
E-mail: huixu@cjlu.edu.cn

b School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China
E-mail: jkgao@zstu.edu.cn

Abstract

A pyrene-based HOF (PFC-1) enables excimer-to-monomer switching that affords the first ratiometric fluorescence discrimination of four similar monoamine neurotransmitters (5-HT, NE, Adr, DA). PFC-1 shows rapid response and high sensitivity, including a 36 nM LOD for 5-HT, and can be integrated into a smartphone platform for portable, point-of-care detection.

Graphical abstract: Excimer-to-monomer switching in a pyrene HOF for discriminative neurotransmitter sensing

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Article information

DOI
https://doi.org/10.1039/D5CC06426K
Article type
Communication
Submitted
12 Nov 2025
Accepted
11 Dec 2025
First published
11 Dec 2025

Chem. Commun., 2026, Advance Article

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Excimer-to-monomer switching in a pyrene HOF for discriminative neurotransmitter sensing

W. Zhang, Z. Zhang, G. Bai, S. Xu, H. Xu and J. Gao, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06426K

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