Dual-target-activated dual-color molecular probe for imaging analysis of cellular senescence

Linlin Wang; Donghui Hong; Jili Li; Lu Wu; Yinghao Xia; Xinjia Di; Jian Wang; Yuqi Xie; Jun Da; Yanlan Liu

doi:10.1039/D5CC00755K

Dual-target-activated dual-color molecular probe for imaging analysis of cellular senescence†

Linlin Wang,^a Donghui Hong,^a Jili Li,*^a Lu Wu,^a Yinghao Xia,^ab Xinjia Di,^a Jian Wang,^a Yuqi Xie,^a Jun Da^a and Yanlan Liu

*^a

Author affiliations

* Corresponding authors

^a Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China
E-mail: lijili@hnu.edu.cn, ylliu@hnu.edu.cn

^b Hebi Polytechnic, Hebi, Henan 458000, China

Abstract

A dual target-activated dual-color fluorescent senoprobe is developed. Unlike traditional probes that rely on tandem linkage and sequential activation, this design adheres to a principle of independent response and independent reporting, enabling in situ and concurrent imaging analysis of two different biomarkers during cellular senescence.

Chemical Communications

Dual-target-activated dual-color molecular probe for imaging analysis of cellular senescence†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Dual-target-activated dual-color molecular probe for imaging analysis of cellular senescence

Social activity

Search articles by author

Spotlight

Advertisements