Issue 20, 2020

Divergent syntheses of okaramines C, J, L, and S–U

Abstract

The total synthesis of six novel okaramines (C, J, L, and S–U) was accomplished with a precise synthesis scheme involving a few steps and a practical yield of 6.7%–23% was obtained. The significance of this study includes the design of a successful and convenient synthesis method for preparation of 3a-hydroxy-pyrrolo[2,3-b]-indole and C-7 prenylated L-tryptophan derivatives using a nucleophilic attack of cyclopropylazetoindoline and an aza-Claisen rearrangement of N-reverse-prenyl tryptophan, respectively.

Graphical abstract: Divergent syntheses of okaramines C, J, L, and S–U

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2020
Accepted
04 May 2020
First published
04 May 2020

Org. Biomol. Chem., 2020,18, 3848-3852

Divergent syntheses of okaramines C, J, L, and S–U

X. Li, T. Si, Y. Liu, M. Wang and A. S. C. Chan, Org. Biomol. Chem., 2020, 18, 3848 DOI: 10.1039/D0OB00587H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements