One-step facile synthesis of Au@copper–tannic acid coordination core–shell nanostructures as photothermally-enhanced ROS generators for synergistic tumour therapy

Abstract

Integrating reactive oxygen species (ROS)-based catalytic therapy and photothermal therapy into one single nanosystem is an inspiring therapeutic approach for tumours. Herein, multifunctional Au nanoparticles with copper–tannic acid coordination core–shell nanostructures (Au@TACu NSs) were fabricated through a one-step method. The obtained Au@TACu NSs possessed a superior hyperthermic effect for tumour ablation, as well as preferential peroxidase-like activity to induce the production of toxic hydroxyl radicals (˙OH) through the decomposition of H₂O₂ for oxidation therapy. Notably, the hyperthermic effect and GSH-depleting capability of Au@TACu NSs can further amplify ˙OH production, achieving photothermally-enhanced oxidation therapy (PTT/OT). Moreover, such a synergistic therapeutic strategy showed highly efficient inhibition of tumour growth in vivo with unnoticeable tissue damage. Our work provides insights into the use of Au-based nanomaterials as theranostic agents for PTT/OT synergistic tumour therapy.