Ir–Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo

Chenchen Wang; Tianli Zhai; Jie Liu; Hong Yang; Yun Sun; Zhiguo Zhou; Qiang Zhao; Shiping Yang

doi:10.1039/D0CC02641G

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Ir–Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo†

Chenchen Wang,‡^a Tianli Zhai,‡^a Jie Liu,^b Hong Yang,

*^a Yun Sun,

*^c Zhiguo Zhou,

^a Qiang Zhao

^d and Shiping Yang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry and Materials Science, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China
E-mail: yanghong@shnu.edu.cn, shipingy@shnu.edu.cn

^b Institute of Bismuth Science & College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China

^c Department of Research and Development and Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai 201321, China
E-mail: yun.sun@sphic.org.cn

^d Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China

Abstract

We report a bimetallic complex [Ir₄Ho₂(pq)₈(H₂dcbpy)₄(OAc)₂] (denoted as Ir₄Ho₂, pq = 2-phenylquinoline, H₂dcppy = 2,2′-bipyridine-3,3′-dicarboxylic acid) and its application for radiotherapy/radiodynamic therapy (RT/RDT). In a tumor xenograft mouse model, Ir₄Ho₂ exerted a tumor-suppressive effect through efficient low-dose RT/RDT.

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DOI: https://doi.org/10.1039/D0CC02641G
Article type: Communication
Submitted: 12 Apr 2020
Accepted: 12 May 2020
First published: 13 May 2020

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Chem. Commun., 2020,56, 6193-6196

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Ir–Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo

C. Wang, T. Zhai, J. Liu, H. Yang, Y. Sun, Z. Zhou, Q. Zhao and S. Yang, Chem. Commun., 2020, 56, 6193 DOI: 10.1039/D0CC02641G

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Chemical Communications

Ir–Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo†

Abstract

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Ir–Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo

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