Issue 42, 2020

Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation

Abstract

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

Graphical abstract: Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation

Supplementary files

Article information

Article type
Communication
Submitted
22 Mar 2020
Accepted
24 Apr 2020
First published
24 Apr 2020

Chem. Commun., 2020,56, 5597-5600

Author version available

Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation

J. Lee, R. Torres, D. S. Kim, M. Byrom, A. D. Ellington and M. C. Jewett, Chem. Commun., 2020, 56, 5597 DOI: 10.1039/D0CC02121K

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