Issue 42, 2020

Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

Abstract

We show that the equilibrium of intramolecular spirocyclization of coumarin–hemicyanine hybrid fluorophores can be finely tuned by means of chemical modifications. We used this scaffold to develop activatable fluorescent probes with large Stokes shifts for γ-glutamyltranspeptidase and esterase.

Graphical abstract: Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2020
Accepted
30 Mar 2020
First published
30 Mar 2020

Chem. Commun., 2020,56, 5617-5620

Author version available

Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

H. Fujioka, S. Uno, M. Kamiya, R. Kojima, K. Johnsson and Y. Urano, Chem. Commun., 2020, 56, 5617 DOI: 10.1039/D0CC00559B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements