Issue 21, 2020
From the journal:

Chemical Communications

A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells†

Xiaojing Xing,‡*abc   Jin Li,‡c   Liping Qiu ORCID logo *ac  and  Weihong Tan ORCID logo c  

* Corresponding authors

a NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410000, China
E-mail: qiuliping@hnu.edu.cn

b Engineering Technology Research Center of Henan Province for Solar Catalysis, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061, China
E-mail: xjxing@hnu.edu.cn

c Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Abstract

We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manipulation.

Graphical abstract: A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells

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Article information

DOI
https://doi.org/10.1039/C9CC09682E
Article type
Communication
Submitted
13 Dec 2019
Accepted
30 Jan 2020
First published
30 Jan 2020

Chem. Commun., 2020,56, 3131-3134

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A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells

X. Xing, J. Li, L. Qiu and W. Tan, Chem. Commun., 2020, 56, 3131 DOI: 10.1039/C9CC09682E

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