Issue 10, 2020
From the journal:

Chemical Communications

A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission†

Zhe Chen,ab   Jingxiong Lu,bc   Fan Xiao,b   Yishun Huang,b   Xuanjun Zhang ORCID logo *a  and  Leilei Tian ORCID logo *b  

* Corresponding authors

a Cancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China
E-mail: xuanjunzhang@um.edu.mo

b Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, China
E-mail: tianll@sustech.edu.cn

c Institute of Medi-X, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, China

Abstract

A new DNA nanoprobe based on a Y-shape and pyrene-modified DNA self-assembly is developed to sensitively and specifically detect microRNA through a pyrene excimer–monomer switch. Exhibiting the capability of self-delivery and resistance to nuclease degradation, the nanoprobe has been successfully applied for microRNA imaging in live cells.

Graphical abstract: A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission

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Article information

DOI
https://doi.org/10.1039/C9CC08093G
Article type
Communication
Submitted
15 Oct 2019
Accepted
23 Dec 2019
First published
28 Dec 2019

Chem. Commun., 2020,56, 1501-1504

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A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission

Z. Chen, J. Lu, F. Xiao, Y. Huang, X. Zhang and L. Tian, Chem. Commun., 2020, 56, 1501 DOI: 10.1039/C9CC08093G

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