Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC

Qian Xie; Mareike M. Wiedmann; Aishan Zhao; Ivelisse R. Pagan; Richard P. Novick; Hiroaki Suga; Tom W. Muir

doi:10.1039/D0CC04873A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC†

Qian Xie,

‡^a Mareike M. Wiedmann,

§‡^b Aishan Zhao,

¶‡^a Ivelisse R. Pagan,^c Richard P. Novick,^c Hiroaki Suga

*^b and Tom W. Muir

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Princeton University, Princeton, NJ, USA
E-mail: muir@princeton.edu

^b Department of Chemistry, University of Tokyo, Graduate School of Science, Tokyo, Japan
E-mail: hsuga@chem.s.u-tokyo.ac.jp

^c Skirball Institute, Department of Microbiology, NYU Medical Center, New York, NY, USA

Abstract

We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

Download options Please wait...

Supplementary files

Supplementary information PDF (3323K)

Article information

DOI: https://doi.org/10.1039/D0CC04873A
Article type: Communication
Submitted: 15 Jul 2020
Accepted: 29 Jul 2020
First published: 29 Jul 2020

Download Citation

Chem. Commun., 2020,56, 11223-11226

Permissions

Request permissions

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC

Q. Xie, M. M. Wiedmann, A. Zhao, I. R. Pagan, R. P. Novick, H. Suga and T. W. Muir, Chem. Commun., 2020, 56, 11223 DOI: 10.1039/D0CC04873A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC

Social activity

Search articles by author

Spotlight

Advertisements