Issue 8, 2005
From the journal:

Chemical Communications

Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes†

Russell J. Cox,*a   Dougal J. Ritson,a   Thomas A. Dane,a   John Berge,b   Jonathan P. H. Charmantc  and  Anob Kantachac  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: r.j.cox@bris.ac.uk
Fax: +44 (0)117 9298611

b GlaxoSmithKline, New Frontiers Science Park (North), 3rd Avenue, Harlow, Essex, UK

c Structural Chemistry Laboratory, School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK

Abstract

Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.

Graphical abstract: Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes

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Article information

DOI
https://doi.org/10.1039/B414826F
Article type
Communication
Submitted
27 Sep 2004
Accepted
29 Oct 2004
First published
10 Jan 2005

Chem. Commun., 2005, 1037-1039

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Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes

R. J. Cox, D. J. Ritson, T. A. Dane, J. Berge, J. P. H. Charmant and A. Kantacha, Chem. Commun., 2005, 1037 DOI: 10.1039/B414826F

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