Issue 24, 2019

Recent advances in the direct functionalization of quinoxalin-2(1H)-ones

Abstract

The direct C3-functionalization of quinoxalin-2(1H)-ones via C–H bond activation has recently attracted considerable attention, due to their diverse biological activities and chemical properties. This review will focus on the recent achievements, mainly including arylation, alkylation, acylation, alkoxycarbonylation, amination, amidation and phosphonation of quinoxalin-2(1H)-ones. Their mechanisms are also discussed.

Graphical abstract: Recent advances in the direct functionalization of quinoxalin-2(1H)-ones

Article information

Article type
Review Article
Submitted
04 Apr 2019
Accepted
18 May 2019
First published
23 May 2019

Org. Biomol. Chem., 2019,17, 5863-5881

Recent advances in the direct functionalization of quinoxalin-2(1H)-ones

Q. Ke, G. Yan, J. Yu and X. Wu, Org. Biomol. Chem., 2019, 17, 5863 DOI: 10.1039/C9OB00782B

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