Issue 9, 2019

Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

Abstract

Quinazolinones have broad applications in the biological, pharmaceutical and material fields. Studies on the synthesis of these compounds are therefore widely conducted. Herein, a novel and highly efficient copper-mediated tandem C(sp2)–H amination and annulation of benzamides and amidines for the synthesis of quinazolin-4(1H)-ones is proposed. This synthetic route can be useful for the construction of quinazolin-4(1H)-one frameworks.

Graphical abstract: Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

Supplementary files

Article information

Article type
Communication
Submitted
04 Jan 2019
Accepted
06 Feb 2019
First published
07 Feb 2019

Org. Biomol. Chem., 2019,17, 2356-2360

Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

F. Hu, X. Cui, Z. Ban, G. Lu, N. Luo and G. Huang, Org. Biomol. Chem., 2019, 17, 2356 DOI: 10.1039/C9OB00020H

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