In this study, a concise and atom-economical TfOH-mediated [2 + 2 + 2] cycloaddition of ynamides with two discrete nitriles is developed to synthesize multi-substituted 4-aminopyrimidine. A variety of functional groups and sterically and electronically diverse reaction partners are tolerated. The products were obtained in good to excellent yields.
![Graphical abstract: TfOH-mediated [2 + 2 + 2] cycloadditions of ynamides with two discrete nitriles: synthesis of 4-aminopyrimidine derivatives](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6RA11408C&imageInfo.ImageIdentifier.Year=2016)
P. Chen, C. Song, W. Wang, X. Yu and Y. Tang, RSC Adv., 2016, 6, 80055 DOI: 10.1039/C6RA11408C
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