The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

Didier F. Vargas; Enrique L. Larghi; Teodoro S. Kaufman

doi:10.1039/C8NP00014J

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The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

Didier F. Vargas,

^a Enrique L. Larghi

^a and Teodoro S. Kaufman

*^a

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* Corresponding authors

^a Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas – Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
E-mail: kaufman@iquir-conicet.gov.ar

Abstract

Covering: 2006 to 2018

The application of the 6π-azaelectrocyclization of azatrienes as a key strategy for the synthesis of natural products, their analogs and related bioactive or biomedically-relevant compounds (from 2006 to date) is comprehensively reviewed. Details about reaction optimization studies, relevant reaction mechanisms and conditions are also discussed.

Graphical abstract: The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

This article is part of the themed collection: Celebrating Latin American Talent in Chemistry

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Article information

DOI: https://doi.org/10.1039/C8NP00014J
Article type: Review Article
Submitted: 08 Feb 2018
First published: 09 Aug 2018

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Nat. Prod. Rep., 2019,36, 354-401

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The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

D. F. Vargas, E. L. Larghi and T. S. Kaufman, Nat. Prod. Rep., 2019, 36, 354 DOI: 10.1039/C8NP00014J

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The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

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