Selective mono- and dimetallation of a group 3 sandwich complex

Abstract

The scandium Cp/COT hybrid sandwich compound [(η⁵-C₅H₅)Sc(η⁸-C₈H₈)] is resistant to metallation via conventional alkyllithium and lithium amide bases. In this work, clean, selective, stoichiometric and high-yielding mono- and dimetallation is accomplished using tandem trans-metal-trapping (TMT) involving LiTMP and iBu₂AlTMP with deprotonation occurring selectively at the Cp and Cp/COT rings respectively, providing the first examples of selective metallation of a sandwich complex featuring a group 3 element.