Issue 11, 2013
From the journal:

Dalton Transactions

Cationic arene ruthenium(ii) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxideligands as potent anticancer agents†‡

Gerd Ludwig,a   Goran N. Kaluđerović,ab   Tobias Rüffer,c   Martin Bette,a   Marcus Korb,c   Michael Block,a   Reinhard Paschke,b   Heinrich Langc  and  Dirk Steinborn*a  

* Corresponding authors

a Institute of Chemistry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 2, D-06120 Halle, Germany
E-mail: dirk.steinborn@chemie.uni-halle.de

b Biocenter, Martin Luther University Halle-Wittenberg, Weinbergweg 22, D-06120 Halle, Germany

c Institute of Chemistry, Chemnitz University of Technology, Straße der Nationen 62, D-09111 Chemnitz, Germany

Abstract

The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(η6-p-cym)Cl{Ph2P(CH2)nS(O)xPh-κP,κS}][PF6] (n = 1–3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure–activity relationships are discussed.

Graphical abstract: Cationic arene ruthenium(ii) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

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Article information

DOI
https://doi.org/10.1039/C3DT33064H
Article type
Communication
Submitted
21 Dec 2012
Accepted
09 Jan 2013
First published
09 Jan 2013

Dalton Trans., 2013,42, 3771-3774

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Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

G. Ludwig, G. N. Kaluđerović, T. Rüffer, M. Bette, M. Korb, M. Block, R. Paschke, H. Lang and D. Steinborn, Dalton Trans., 2013, 42, 3771 DOI: 10.1039/C3DT33064H

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