Issue 18, 2023

Palladium nanocatalyst assisted in situ regeneration of amino donor in a one-enzyme cascade

Abstract

α-Chiral amines are key intermediates for scalable preparation of bioactive compounds; herein we present a novel palladium-based nanocatalyst capable of selectively catalyzing the reductive amination of carbonyl compounds, which enables the in situ regeneration of amino donors from wasteful co-products in a one-enzyme cascade using ω-transaminase, without the requirement of the expensive coenzyme NAD(P)H. The cascade network combines a ω-transaminase-assisted transamination with a selective reductive amination reaction facilitated by a heterogeneous palladium-based nanocatalyst. Nitrogen is sourced from hydroxylamine ions to convert generated co-products back into amino donors, yielding chiral amines with exceptional yields of up to 99% and excellent enantioselectivity. This chemoenzymatic one-enzyme transamination-reductive amination cascade network is highly atom-efficient and generates H2O as its sole by-product, demonstrating its potential impact in synthetic chemistry and beyond.

Graphical abstract: Palladium nanocatalyst assisted in situ regeneration of amino donor in a one-enzyme cascade

Supplementary files

Article information

Article type
Paper
Submitted
25 May 2023
Accepted
18 Aug 2023
First published
21 Aug 2023

Green Chem., 2023,25, 7372-7380

Palladium nanocatalyst assisted in situ regeneration of amino donor in a one-enzyme cascade

R. Wang, X. Tang, X. Jv, Y. Liu and B. Wang, Green Chem., 2023, 25, 7372 DOI: 10.1039/D3GC01786A

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