Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

Shaofa Sun; Rongxing Chen; Gangqiang Wang; Jian Wang

doi:10.1039/C8OB02321B

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Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates†

Shaofa Sun,^a Rongxing Chen,^ab Gangqiang Wang*^a and Jian Wang

*^b

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* Corresponding authors

^a Non-power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, China
E-mail: wgq20008@163.com

^b School of Pharmaceutical Sciences, Tsinghua University, Beijing, China
E-mail: wangjian2012@tsinghua.edu.cn

Abstract

A new [3 + 2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as a broad substrate scope and good functional group tolerance.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB02321B
Article type: Communication
Submitted: 19 Sep 2018
Accepted: 11 Oct 2018
First published: 11 Oct 2018

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Org. Biomol. Chem., 2018,16, 8011-8014

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Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

S. Sun, R. Chen, G. Wang and J. Wang, Org. Biomol. Chem., 2018, 16, 8011 DOI: 10.1039/C8OB02321B

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Organic & Biomolecular Chemistry

Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates†

Abstract

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Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

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