Issue 20, 2018

Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

Abstract

Herein we present a new strategy for the dehydrogenative–decarboxylative coupling of indoles with glyoxylic acid. A broad range of indoles were transformed into the corresponding 3-formylindoles in moderate to good yields and excellent functional group tolerance. Notably, no N-formylation product was detected under our conditions.

Graphical abstract: Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2018
Accepted
28 Apr 2018
First published
30 Apr 2018

Org. Biomol. Chem., 2018,16, 3707-3710

Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

Z. Yin, Z. Wang and X. Wu, Org. Biomol. Chem., 2018, 16, 3707 DOI: 10.1039/C8OB00810H

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