Issue 18, 2018
From the journal:

Organic & Biomolecular Chemistry

A concise total synthesis of cochlearoid B†

Wuxia Zhang,abc   Dehai Xiao*ab  and  Bo Wang ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Synthetic Rubber, Chinese Academy of Sciences, Changchun 130022, China
E-mail: wangbo@ciac.ac.cn, dhxiao@ciac.ac.cn

b Green Chemistry and Process Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

c University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

A T-type calcium channel inhibiting natural product cochlearoid B was synthesized for the first time in 7 linear steps via a convergent strategy exploiting the Suzuki–Miyaura cross coupling and the acid promoted Prins cyclization cascade. This strategy allows rapid access to its structural analogues for further therapeutical development.

Graphical abstract: A concise total synthesis of cochlearoid B

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Article information

DOI
https://doi.org/10.1039/C8OB00615F
Article type
Communication
Submitted
12 Mar 2018
Accepted
05 Apr 2018
First published
10 Apr 2018

Org. Biomol. Chem., 2018,16, 3358-3361

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A concise total synthesis of cochlearoid B

W. Zhang, D. Xiao and B. Wang, Org. Biomol. Chem., 2018, 16, 3358 DOI: 10.1039/C8OB00615F

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