Issue 66, 2023
From the journal:

Chemical Communications

Fluorene-based tau fibrillation sensor and inhibitor with fluorogenic and photo-crosslinking properties†

Qiuxuan Xia,‡ab   Zhiming Wang,‡ac   Wang Wan, ORCID logo a   Huan Feng,ab   Rui Sun,ab   Biao Jing,ac   Yusong Ge*c  and  Yu Liu ORCID logo *a  

* Corresponding authors

a CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
E-mail: liuyu@dicp.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

c The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Dalian, China

Abstract

Tau protein aggregation into neurofibrillary tangles often causes tauopathies. Herein, we report fluorene based sensors with fluorogenicity upon binding to tau proteins. Intriguingly, these sensors possess triplet state properties to inhibit tau fibrillation upon photo-induced crosslinking.

Graphical abstract: Fluorene-based tau fibrillation sensor and inhibitor with fluorogenic and photo-crosslinking properties

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Article information

DOI
https://doi.org/10.1039/D3CC02581K
Article type
Communication
Submitted
29 May 2023
Accepted
24 Jul 2023
First published
24 Jul 2023

Chem. Commun., 2023,59, 10008-10011

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Fluorene-based tau fibrillation sensor and inhibitor with fluorogenic and photo-crosslinking properties

Q. Xia, Z. Wang, W. Wan, H. Feng, R. Sun, B. Jing, Y. Ge and Y. Liu, Chem. Commun., 2023, 59, 10008 DOI: 10.1039/D3CC02581K

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