Issue 6, 2019

Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

Abstract

The employment of an ancillary amine-substituted bisphosphonate ligand affords a dicobalt complex able to quantitate pH with a remarkably high sensitivity of 8.8(5) pH unit−1 at 37 °C through a ratiometric paramagnetic chemical exchange saturation transfer (PARACEST) approach, where the different pH dependences of amine and amide CEST peak intensities are utilized.

Graphical abstract: Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

Supplementary files

Article information

Article type
Communication
Submitted
30 Nov 2018
Accepted
14 Dec 2018
First published
14 Dec 2018

Chem. Commun., 2019,55, 794-797

Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

A. E. Thorarinsdottir and T. D. Harris, Chem. Commun., 2019, 55, 794 DOI: 10.1039/C8CC09520E

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