Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(II)–curcumin organometallic conjugate

Sankarasekaran Shanmugaraju; Bjørn la Cour Poulsen; Tobi Arisa; Deivasigamani Umadevi; Hannah L. Dalton; Chris S. Hawes; Sandra Estalayo-Adrián; Aramballi J. Savyasachi; Graeme W. Watson; D. Clive Williams; Thorfinnur Gunnlaugsson

doi:10.1039/C8CC01584H

Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(ii)–curcumin organometallic conjugate†

Sankarasekaran Shanmugaraju,

*^a Bjørn la Cour Poulsen,^a Tobi Arisa,^a Deivasigamani Umadevi,

^b Hannah L. Dalton,^a Chris S. Hawes,

^ac Sandra Estalayo-Adrián,

^a Aramballi J. Savyasachi,^a Graeme W. Watson,

^b D. Clive Williams^d and Thorfinnur Gunnlaugsson

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland
E-mail: shanmugs@tcd.ie, gunnlaut@tcd.ie

^b School of Chemistry and Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland

^c School of Chemical and Physical Sciences, Keele University, Keele, UK

^d School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, Dublin-2, Ireland

Abstract

The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1–TB-3) and a new Tröger's base p-cymene–Ru(II)–curcumin organometallic conjugate (TB–Ru–Cur) are described; these compounds showed fast cellular uptake and displayed good luminescence and cytotoxicity against cervical cancer cells.

Chemical Communications

Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(ii)–curcumin organometallic conjugate†

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Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(II)–curcumin organometallic conjugate

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