Issue 32, 2018

Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR

Abstract

We report solid-state Nuclear Magnetic Resonance (ssNMR) studies on amyloid-like protein complexes formed by DIX domains that mediate key protein interactions in the Wnt signalling pathway. Our results provide insight into the 3D fold of the self-associated Axin-DIX domain and identify a potential lipid cofactor.

Graphical abstract: Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2018
Accepted
14 Mar 2018
First published
21 Mar 2018

Chem. Commun., 2018,54, 3959-3962

Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR

M. E. Ward, M. A. Daniëls, E. C. van Kappel, M. M. Maurice and M. Baldus, Chem. Commun., 2018, 54, 3959 DOI: 10.1039/C8CC01346B

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