One-pot oximation-Beckmann rearrangement under mild, aqueous micellar conditions

Abstract

A sustainable and eco-friendly approach to the Beckmann rearrangement has been developed, leveraging nanomicelles to facilitate the reaction in water under mild conditions. This process efficiently transforms functionalized ketones into corresponding amides in a one-pot sequence, achieving high yields of up to 96%. It is more appealing compared to traditional methods, which require significant amounts of organic solvents. The scalability and robustness of this procedure demonstrate its potential for the synthesis of valuable compounds such as paracetamol and ε-caprolactam.