Revealing the elevation of Zn2+ in the brain of depressed mice by a ratiometric fluorescent probe with dual near-infrared emissions

Haobin Jin; Can Ju; Chenxu Duan; Ningwen Zhang; Yongyong Cao; Qineng Xia; Jin Zhou; Shumei Gao; Yangang Wang; Hong Huang

doi:10.1039/D3CC05529A

Revealing the elevation of Zn²⁺ in the brain of depressed mice by a ratiometric fluorescent probe with dual near-infrared emissions†

Haobin Jin,^a Can Ju,^a Chenxu Duan,^a Ningwen Zhang,^a Yongyong Cao,^a Qineng Xia,^a Jin Zhou,

*^b Shumei Gao,^a Yangang Wang*^a and Hong Huang

*^a

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* Corresponding authors

^a College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
E-mail: ygwang8136@zjxu.edu.cn, huangho17@zjxu.edu.cn

^b School of Pharmacy, Weifang Medical University, Weifang 261053, China
E-mail: zhoujin@wfmc.edu.cn

Abstract

A mitochondria-targeted ratiometric fluorescent probe (Mito-Zn) was first designed and synthesized with dual emissions both located in the near-infrared region, for Zn²⁺ detection with high sensitivity and selectivity. By using the developed Mito-Zn, a high level of Zn²⁺ in the depressed mouse brain was discovered for the first time.

Chemical Communications

Revealing the elevation of Zn²⁺ in the brain of depressed mice by a ratiometric fluorescent probe with dual near-infrared emissions†

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Revealing the elevation of Zn²⁺ in the brain of depressed mice by a ratiometric fluorescent probe with dual near-infrared emissions

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