Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles

The scope and mechanism of aza-Heck methodologies that provide chiral heterocyclic systems are outlined.


Introduction
Nitrogen-containing molecules hold a privileged position in drug discovery. In 2013, eighty percent of the top twenty bestselling brand name drugs incorporated nitrogen, with two thirds of these compounds containing an N-heterocycle. 1 In particular, chiral pyrrolidine and piperidine derivatives are common in pharmaceuticals and alkaloid natural products. 2 With these considerations in mind, the development of efficient and versatile routes to complex molecular structures, particularly those containing C(sp 3 )-N bonds, is of paramount importance. 3 In this perspective, we highlight the emerging area of aza-Heck reactions for the synthesis of chiral nitrogen heterocycles. Here, an activated N-O bond replaces the C-X bond (X ¼ halide, OTf) used in conventional Heck reactions, with the resulting aza-Pd(II) intermediates mimicking the reactivity of their aryl-Pd(II) counterparts (Scheme 1). In general terms, aza-Heck reactions can be considered complementary to more well- established aza-Wacker processes that require an external oxidant. 4 However, as will be seen, the use of an N-O bond as the internal oxidant can confer several synthetic and mechanistic advantages. The following discussion highlights key historical developments in aza-Heck chemistry before focussing on the scope and mechanism of methodologies that provide chiral heterocyclic systems.
The Narasaka-Heck reaction and early heteroaromatic methodologies The prototypical aza-Heck process was reported in 1999 by Narasaka and co-workers. In this seminal work, exposure of g,dunsaturated pentauorobenzoyl oxime ester 1 ( F Bz ¼ penta-uorobenzoyl) to 10 mol% Pd(PPh 3 ) 4 effected cyclization to pyrrole 2 in 81% yield (Scheme 2). 5 A variety of other systems were shown to cyclize efficiently, providing a direct and exible entry to differentially substituted pyrroles. The proposed mechanism involves elementary steps that are analogous to the conventional Heck reaction, 6 with the process later becoming known as the 'Narasaka-Heck reaction'. 7 Specically, oxidative addition of Pd(0) into the N-O bond of 1 generates key imino-Pd(II) intermediate 3; this initiation step replaces the C-X oxidative addition step of the conventional Heck reaction. From 3, migratory insertion of the alkene into the Pd-N bond (5-exo imino-palladation) 8 is followed by b-hydride elimination and alkene isomerization to deliver the pyrrole target. Importantly, the geometry of the oxime ester moiety of 1 is inconsequential, such that both isomers cyclize with comparable efficiencies.
Presumably, E/Z isomerization occurs at the stage of imino-Pd(II) intermediate 3, although the mechanism of this process is not well understood. Imino-Pd(II) intermediates related to 3 have been characterized crystallographically by the groups of Hartwig 9 and Stahl, 10 providing unambiguous conrmation of the N-O oxidative addition event.
Following Narasaka's initial report, a variety of related heteroaromatic methodologies emerged (Scheme 3). A key feature of all of these approaches is that the oxime ester substrates are readily available from the corresponding ketones, which, in turn, can be accessed using well-established carbonyl chemistry (Scheme 3A). In most cases, O-pentauorobenzoyl oxime esters are required, although processes that exploit oxidative addition into the N-O bond of O-phosphinyl oxime esters 11 or the N-N bond of N,N,N-trimethylhydrazonium salts have also been developed. 12  that cyclization of such systems proceeds via a radical-based pathway. 13 A representative outline of heteroaromatic compounds accessible via the Narasaka-Heck reaction is presented in Scheme 3B. Pyridines 5 can be accessed by 6-endo cyclization of oxime esters 4; here, chloride additives such as LiCl and n-Bu 4 NCl were found to play a crucial role. 14 Abell and co-workers showed that amidoxime esters 6 cyclize to afford imidazoles 7, thereby demonstrating the viability of N-O oxidative addition beyond oxime ester substrates. 15 In conformationally constrained cases, 6-exo cyclizations are feasible; for example, isoquinolines 9 can be accessed by aza-Heck cyclization of precursors 8. 16 Other classes of acceptor can also be exploited. For example, cyclization onto pendant cycloheptatrienes generates aza-azulenes aer in situ oxidation of the initial aza-Heck adduct (10 to 11). 17 The processes discussed so far use the Narasaka-Heck reaction to generate new C(sp 2 )-N bonds, 18 rendering these approaches ideally suited to the synthesis of N-heteroaromatic compounds. Given the increasing importance of chiral Nheterocycles in the pharmaceutical industry, 2 generalization of aza-Heck manifolds to the formation of (stereodened) C(sp 3 )-N bonds is particularly appealing. The remainder of this Perspective highlights recent aza-Heck methodologies that use N-O bonds to generate chiral nitrogen heterocycles. 19 As will be seen, processes that initiate at the N-O bond of oxime esters, as used in the original Narasaka process, have received the most attention. However, recent reports have exploited other redox active N-O donors, such that N-(penta-uorobenzoyloxy)sulfonamide 20 and O-phenyl hydroxamates 21 are now viable initiating motifs for aza-Heck cyclizations (Scheme 4). Chiral N-heterocycles via Narasaka-Heck cyclizations: mechanism and reaction scope In 2012, the rst systematic efforts to exploit aza-Heck cyclizations of oxime esters for the synthesis of C(sp 3 )-N bonds, and therefore chiral N-heterocycles, were reported by our group. Initial studies explored cyclizations onto cyclic alkenes because the stereoelectronic requirements of syn-iminopalladation and syn-b-hydride elimination were expected to result in the formation of C(sp 3 )-N bonds. 22 Indeed, an example of this type of cyclization had been reported in 2005 by Fürstner and coworkers in the context of a natural product synthesis (Scheme 5). 23 In this process, a symmetrical bis-olenic acceptor unit was specically incorporated into 12 to offset inherent inefficiencies associated with imino-palladation. Even using this biasing factor, high loadings of Pd catalyst were required to achieve a relatively modest yield of target 13. At the time, these issues were reective of wider difficulties in promoting efficient aza-Heck cyclizations over diverse substrate classes.
With the aim of developing a general aza-Heck methodology involving cyclic alkenes, oxime ester 14 was used as a model substrate (Scheme 6A). 22 Extensive investigations revealed that efficient cyclization to 15 was possible, but only when electron-decient phosphine ligands were used. By far the most effective subset of ligands were uorinated triarylphosphines, with P(3,5-(CF 3 ) 2 C 6 H 3 ) 3 emerging as the optimal system (Scheme 6B). This ligand allowed cyclization of 14 to proceed in 93% yield at 60 C with 5 mol% Pd loading. Highly electron-decient phosphine ligands, such as P(C 6 F 5 ) 3 were not effective and low conversions were observed, likely due to slow N-O oxidative addition. However, within the effective ligand range outlined in Scheme 6B, oxidative addition does not appear to be rate limiting such that the choice of ligand is dictated by the efficiency of steps later in the cycle. Interestingly, bulky electron-rich phosphine ligands, such as those typically employed in conventional Heck reactions (where oxidative addition is oen rate limiting), are not effective and lead to a different mechanistic pathway (vide infra).
The benecial effects of P(3,5-(CF 3 ) 2 C 6 H 3 ) 3 are consistent with stoichiometric studies by Hartwig and co-workers, who demonstrated that migratory insertion of alkenes into Pd-NPh 2 bonds is facilitated by bulky and/or electron-decient ligands. 24 An additional key factor for the conversion 14 to 15 resides in suppression of protodepalladation of imino-Pd intermediate 16. Electron-decient phosphine ligands are expected to increase s-donation from the imino moiety, which, in turn, should suppress competing protonation of this unit. Indeed, under unoptimized conditions, protodepalladation dominates, leading to ketone by-product 19, likely via the intermediacy of hydrolytically sensitive NH imine 18.
Also of considerable importance for the cyclization of 14 to 15 is the pentauorobenzoate leaving group. This activating group was introduced in Narasaka's seminal publication as a result of empirically driven studies; 5 substrates of this type were found to offer the best balance of starting material stability and catalytic activity. With respect to the former aspect, the key issue is suppression of competing Beckmann rearrangement of the starting material, which becomes problematic when more polarizing activating groups (e.g. O-sulfonyl groups) are used. Nevertheless, the requirement of a pentauorobenzoate leaving group for the cyclization of 14 was striking given that Uemura and co-workers have shown that facile oxidative addition of Pd(0) into the N-O bond of less polarized O-benzoyl oximes can be used to trigger b-carbon eliminations. 25 Note that the Uemura process does not involve alkene imino-palladation, suggesting a critical role for the leaving group on the efficiency of this step in aza-Heck reactions.
Investigations aimed at understanding the efficiencies of different leaving groups (in particular pentauorobenzoate vs. benzoate) revealed that, for the cyclization of 14 to 15, addition of exogenous C 6 F 5 CO 2 H or C 6 H 5 CO 2 H decreases both the reaction rate and yield. 26 Furthermore, halide additives, such as n-Bu 4 NCl, completely suppress aza-Heck cyclization. These studies suggest that, for efficient cyclization, the leaving group must dissociate aer oxidative addition to provide cationic imino-Pd(II) intermediate 17 (Scheme 6A). Relatively electron-rich carboxylates, such as benzoate, do not dissociate readily, resulting in less efficient cyclization of 14 and increased levels of protodepalladation at the stage of imino-Pd(II) intermediate 16. 19 F NMR studies revealed a surprising additional benet of the pentauorobenzoate leaving group. It was found the interaction of this by-product with protonated triethylamine, which is generated by deprotonation of the Pd-hydride species released upon b-hydride elimination, results in facile protodecarboxylation to C 6 F 5 H. This process removes otherwise inhibitory pentauorobenzoate from the reaction system, such that equilibrium access to cationic imino-Pd(II) intermediate 17 is maintained in subsequent cycles. In favorable cases, the protodecarboxylation process allows substoichiometric (catalytic) quantities of Et 3 N to be used. Thus, efficient aza-Heck cyclization is dependent on both a pentauorobenzoate leaving group and an electron-decient phosphine. A complete mechanistic picture of the aza-Heck cyclization of 14 to 15, as discussed above, is outlined in Scheme 7.
The conditions optimized for 14 proved to be generally applicable for 5-exo aza-Heck cyclizations onto cyclic alkenes (Scheme 8). 22 Indeed, a variety of aryl-, alkyl-, and heteroarylsubstituted oxime esters underwent efficient aza-Heck reaction to give the corresponding cis-fused bicyclic Nheterocycles in high yield (Scheme 8A). Cyclic alkenes of different ring sizes were also tolerated, as well as systems with substitution at C2 of the oxime ester. Interestingly, oxime ester 20a, which possesses a non-dened a-stereocenter, underwent stereoconvergent cyclization to generate bicyclic system 21a in high diastereopurity; a similar result was observed for 21b (Scheme 8B). Presumably, initial cyclization of both diastereomers is followed by equilibration (via the enamine) to the thermodynamically favored product, wherein the R 2 -substituent resides on the less hindered face of the dihydropyrrole ring.
An inherent consequence of using the Narasaka-Heck cyclization to generate C(sp 3 )-N bonds is that the product contains imine and alkene units for further derivatization. Oxime ester (R)-14 (93% e.e.) underwent diastereoselective aza-Heck cyclization to afford N-heterocycle (3aR,7aS)-15 without loss of enantiomeric purity (Scheme 9). Further manipulation of this product via the imine and alkene afforded complex bicyclic system 22 with high levels of control for all ve stereocenters. The sequence in Scheme 9 demonstrates the power of aza-Heck methodology for the formation of complex, chiral Nheterocycles.
Further studies sought to investigate the scope of the Pd 2 (dba) 3 /P(3,5-(CF 3 ) 2 C 6 H 3 ) 3 catalyst system with respect to other classes of alkene acceptor. It was found that cyclizations of oxime esters with 1,1-disubstituted alkenes (Scheme 10) provides a general entry to a,a-disubstituted systems 24. 27 Here, 5-exo cyclization of 23 generates alkyl-Pd(II) intermediate 25, which can only undergo b-hydride elimination via C7-H to deliver chiral product 24. The process tolerates sterically and electronically diverse substituents at R 1 and R 2 , providing an efficient approach to challenging tetra-substituted nitrogenbearing stereocentres. Ultimately, this study served as the basis for the development of enantioselective variants, as described later.
In the studies outlined above, which involve cyclic or 1,1disubstituted alkenes, the nature of the alkene acceptor enforces the formation of chiral products (new C(sp 3 )-N bond). For processes involving 1,2-disubstituted alkenes, 5-exo cyclization generates alkyl-Pd(II) intermediate 27, from which bhydride elimination can occur via either H a or H b (Scheme 11). The former pathway leads to pyrrole products; Narasaka has shown that cyclisation of 26 using Pd(PPh 3 ) 4 affords pyrrole 28 with 8 : 1 selectivity over dihydropyrrole 29 (73% combined yield). 5 To provide selectivity for chiral products in processes involving 1,2-disubstituted alkenes, strategic installation of an aryl ring at R 2 was explored (Scheme 12). 28,29 This approach proved effective, such that a variety of dihydropyrroles 31a-e were generated from oxime esters 30a-e with high selectivity over the corresponding pyrroles 32a-e. For systems with substitution at C4 (e.g. 31e) good levels of 1,2-diastereocontrol were observed, whereas C3-methyl substituted product 31d was formed in low diastereoselectivity. Gratifyingly, extension of the method to systems where R 2 ¼ alkyl also resulted in selective formation of chiral products (e.g. 30f to 31f). Here, studies on the effects of different ligands revealed that the relatively wide cone angle of P(3,5-(CF 3 ) 2 C 6 H 3 ) 3 is responsible for preferential b-hydride elimination via H b .
The dihydropyrrole products accessed in Scheme 12 are ideally suited to diastereoselective manipulations (Scheme 13). Indeed, hydrogenation of the imine of 31a afforded pyrrolidine 33 in 95% yield and 10 : 1 d.r. Similarly, allyl addition (allylMgCl) to 31a occurred from the less hindered face of the imine to provide 34 in high diastereoselectivity (>20 : 1 d.r.). Bicyclic systems common to many indolizidine alkaloids can also be constructed. For example, DIBAL-H reduction of the imine of 31a was followed by N-butenylation and ring-closing metathesis to afford bicyclic system 35 in high diastereopurity. More stereochemically complex aza-Heck products can also be manipulated, with DIBAL-H reduction of 31e occurring from the face opposite the C2-substituent to provide complex pyrrolidine 36 in >20 : 1 d.r.
Imino-palladation versus iminyl radical cyclization in Narasaka-Heck reactions and a copper-catalyzed protocol The studies described so far highlight the importance of electron-decient ligands for efficient aza-Heck cyclization. In part, this may be due to an enhancement of alkene migratory insertion at the stage of the imino-Pd(II) intermediate. However, another key benet resides in the mechanistic control that such Scheme 10 Aza-Heck cyclization of oxime esters with 1,1-disubstituted alkenes.

Scheme 12
Aza-Heck cyclizations of oxime esters with 1,2-disubstituted alkenes; the ratio of dihydropyrrole 31 : pyrrole 32 is shown in brackets below the isolated yield of pure 31.
Scheme 13 Chiral N-heterocycles accessible from dihydropyrrole product. ligands offer for the N-O oxidative addition step. In early studies, we found that when common electron-rich ligand systems (e.g. 1,1 0 -bis(di-tert-butylphosphino)ferrocene (dt-bpf), P(t-Bu) 3 , PCy 3 etc.) were used for cyclization of oxime ester 14 or pivaloyl variant 37, aza-Heck product 15 was not generated and instead saturated system 40 formed (Scheme 14). 30 Although 40 is formally a reductive aza-Heck product, a series of mechanistic experiments support an alternate radical-based reaction pathway. Indeed, the yield of 40 is enhanced by the inclusion of common hydrogen atom donors, such as g-terpinene, whereas hydride donors offer no appreciable benet. Our collective studies suggest that single-electron transfer from the electronrich Pd(0)-catalyst to 14 or 37 forms iminyl radical 38, with concomitant generation of Pd(I) and carboxylate anion. Fast 5exo cyclization then affords alkyl radical 39, which can abstract a hydrogen atom from g-terpinene to generate 'reductive' aza-Heck product 40 and bis-allylic radical 41. Hydrogen-atom transfer from 41 to Pd(I) affords p-cymene and a Pd(II)hydride, which undergoes base-promoted reductive elimination to regenerate the Pd(0)-catalyst. The process outlined in Scheme 14A is generally applicable, with the unusual hybrid organometallic-radical protocol 31 providing an appealing entry to iminyl radical chemistry. 32 Indeed, products 40a-c were all accessed efficiently using this approach (Scheme 14B).
Overall, the ligand effects revealed during our studies highlight important factors that may impact other processes involving oxidative addition of Pd(0) into the N-O bond of oxime esters. Specically, it appears that electron-neutral or electron-poor Pd(0)-systems undergo N-O oxidative addition via a concerted two-electron redox process, whereas electron-rich Pd-systems can deviate into a SET pathway. For the process in Scheme 14, this pathway is interrupted by fast cyclization of the iminyl radical onto the pendant alkene. In systems without an alkene acceptor, stoichiometric studies from the groups of Hartwig 9 and Stahl 10 have shown that electron-rich Pd-systems (e.g. Pd(0)/PCy 3 ) lead to imino-Pd(II) intermediates. In these cases, it is possible that SET oxidative addition is operative. The mechanistic divergence observed for different phosphine ligands during N-O oxidative addition is reminiscent of the substrate dependent mechanistic divergence oen observed for oxidative addition of Pd(0) into aryl iodides vs. alkyl iodides (concerted vs. SET). 31 In Scheme 14B, iminyl radical cyclization leads to products lacking an alkene. However, under copper-catalyzed conditions we have found that Heck-like products (i.e. those with an alkene) can be accessed using iminyl radical-based cyclizations (Scheme 15). 13b,33 This nding is signicant as it allows the replacement of a rare-earth transition metal catalyst with an isoelectronic rst-row system. Our studies in this area were inspired, in part, by reports from Liebeskind and co-workers, who harnessed copper-based systems to activate the N-O bonds of oxime esters. 34 Under optimized conditions, Cu(2ethylhexanoate) 2 -catalyzed cyclization of a range of pivaloyl oxime esters 42 occurs in good to excellent yields (Scheme 15A). The reaction tolerates cyclic, 1,1-disubstituted and 1,2-disubstituted alkenes, demonstrating similar scope to the afore- a less thermodynamically stable imine (54), such that this detrimental pathway was expected to be slower. 20 A further benet of the approach is that the substrates can be prepared directly by Mitsunobu reaction of the appropriate alcohol with N-(pentauorobenzoyloxy)sulfonamide reagents, which we have found easy to prepare on multi-gram scale. As such, the overall sequence allows the two-step conversion of bis-homoallylic alcohols to chiral pyrrolidine targets.
In the event, the approach outlined in Scheme 16B was successful, providing efficient access to a diverse array of heterocyclic ring systems (Scheme 17). The optimized catalyst system is the same as that described earlier, with ne-tuning of reaction solvent required on a case-by-case basis. Notable features of the process include: (a) selective b-hydride elimination away from nitrogen for cyclizations involving 1,2-disubstituted alkenes (e.g. 57a-b), (b) excellent diastereoselectivities for cyclizations of substrates bearing substituents a to nitrogen (e.g. 57c-d) and (c) the ability to promote challenging 6-exo cyclizations (e.g. 57f). Furthermore, transannular cyclizations are also possible; cyclization of 58 provide tropane ring system 59 in high yield. Mechanistic studies support a reaction pathway analogous to the Narasaka-Heck reaction (see Scheme 7), with protodecarboxylation of the pentauorobenzoate leaving group once again playing a key role.
Conceptually, the approach outlined in Scheme 16B is of broader interest because it uses sulfonamides 55 as bifunctional amino reagents. Specically, the Mitsunobu step exploits the nucleophilic character of 55, whereas the Pd-catalyzed aza-Heck step harnesses the electrophilic reactivity of the N-O bond. As such, further nucleophilic-electrophilic sequences could be envisaged with 55, perhaps leading to a diverse array of methodologies. Studies towards this broad goal are ongoing.
Recently, Watson and co-workers reported a third distinct class of aza-Heck reaction, based on cyclizations of O-phenyl hydroxamates 60 (Scheme 18). 21 The choice of an O-phenyl leaving group was crucial for efficient cyclization, as it suppressed competing Lossen rearrangement of 60. Optimized conditions employ a Pd-system modied with the highly electron decient phosphite P(OCH 2 CF 3 ) 3 . Using this system, 5-exo cyclizations involving a wide range of di-, tri-and tetrasubstituted alkenes were all effective, providing the targets in moderate to excellent yields. 6-Exo cyclizations are also achievable but require conformationally predisposed substrates (e.g. 61f). Note that a secondary O-phenyl hydroxamate is required (R(CO)NHOPh), and N-alkylated systems are not tolerated. The proposed mechanism closely follows those outlined already, with oxidative addition of Pd(0) into the N-O bond of 60 occurring in advance of syn-stereospecic alkene aminopalladation; a series of experiments supported this latter proposition. In contrast to the processes described earlier, it is unclear whether or not this class of aza-Heck cyclization occurs via a cationic aza-Pd intermediate. Indeed, compared to pen-tauorobenzoate, phenoxide is expected to dissociate much less readily, such that in the Watson process cyclization likely occurs in "neutral mode".
The processes outlined in Schemes 17 and 18 could also potentially be achieved using an aza-Wacker approach, wherein the allylic amine targets are generated by Pd(II)-catalyzed cyclization of an NH nucleophile with an alkene under oxidative conditions. 4 Although oen efficient, this approach suffers from several limitations. For example, few cyclizations of primary amides are known under aza-Wacker conditions (cf. Scheme 18), 36 highlighting an inherent limitation of the method. With respect to aza-Wacker cyclizations involving NHsulfonamides (cf. Scheme 17): large a-substituents are not tolerated (cf. 57d), hindered acyclic olens do not participate (cf. 57d) and electron-decient alkenes cannot be used due to competing conjugate addition (cf. 57e). 37 Furthermore, NHsulfonamides required for aza-Wacker cyclization are not prepared directly from the alcohol because the requisite primary sulfonamides do not engage efficiently in conventional Mitsunobu reactions (cf. 55 to 51). Additional advantages of the aza-Heck approach include predictable syn-migratory insertion of the alkene 37c and the ability to use tunable phosphine ligands (because oxidative conditions are avoided).

Alkene 1,2-carboaminations via aza-Heck cascades
In all of the aza-Heck processes discussed so far, the alkyl-Pd(II) intermediate formed aer alkene migratory insertion undergoes b-hydride elimination to generate a new alkene. Further synthetic exibility is potentially enabled by harnessing this intermediate for processes other than b-hydride elimination. 38,39 Such an approach provides an appealing mechanistic framework for the development of synthetically valuable alkene 1,2-carboamination reactions. 40 It has been shown that cascade aza-Heck reactions are possible by using specically designed substrates, bearing multiple alkenes. In 2001, Narasaka reported a series of processes leading to spirocyclic imines (Scheme 19A). 41 In one example, aza-Heck-Heck cyclization of oxime ester 62 generated spirocyclic system 64 in 82% yield. Initial imino-palladation of the 1,1-disubstituted alkene affords intermediate 63, where bhydride elimination is not possible. As such, a second migratory insertion can occur, this time involving the mono-substituted alkene, to deliver ultimately spirocycle 64. Similar cascade reactions have been reported using more recently developed N-O donors (Scheme 19B and C). 20,21 The processes in Scheme 19 involve intramolecular capture of the alkyl-Pd(II) intermediate. 66 in 62% yield. The proposed mechanism involves cyclization and carbonylation to afford cationic acyl-Pd(II) intermediate 67, which is intercepted by the pre-activated tetraarylborate (to give 68), leading to product 66. The choice of a tetraarylborate with a triethylammonium counterion was critical, with this latter component providing the proton required to trigger protodecarboxylation of the otherwise inhibitory penta-uorobenzoate leaving group (cf. Scheme 7). Note that in the oxime ester-based processes described earlier, the necessary proton is generated via the b-hydride elimination step. The carboamination protocol could be extended to other systems (e.g. 69a-e), and alcohols and phenols were also found to be competent nucleophiles, leading to ester products (e.g. 69f). 26,42 Related carbonylative cascades involving alkynyl or vinyl boronates provide ynone and enones targets 70 and 71, respectively (Scheme 21A). Here, the addition of a protic additive was not required, which suggests that the pentauorobenzoate leaving group is sequestered as F BzO-BPin, via Suzuki-like transmetallation from neutral acyl-Pd(II) intermediate 72. Similarly, under non-carbonylative conditions, aryl, vinyl or alkynyl boronates participated to provide 1,2-carboamination products 74a-f from cyclization of oxime esters 73 (Scheme 21B).
The processes in Schemes 20 and 21 demonstrate that N-O oxidative addition can serve as the basis for a diverse suite of alkene 1,2-carboamination reactions. Specically, 1,2-aminoacylation, -carboxylation, -vinylation, -arylation and -alkynylation reactions are all achieved within a unied mechanistic framework. Other redox-neutral Pd-catalyzed methods for alkene 1,2-aminoarylation exploit oxidative addition into the incoming C-based fragment, 40b,c,e,f and cannot access carbonylative products such as 66. Conversely, carbonylative aza-Wacker cyclizations, which are oxidative processes, provide 1,2-aminocarboxylation products (cf. 69f), but do not tolerate organometallic nucleophiles because these effect reduction of the active Pd(II)-catalyst. 40d Accordingly, this manifold does not provide access to, for example, 1,2-aminoarylation products.
Given the new aza-Heck N-O donors that have recently been developed (vide supra), it is likely that further variants of the "umpoled" alkene 1,2-carboamination strategy summarized here will emerge in the near future.

Enantioselective aza-Heck reactions
From the discussion so far, it is clear that aza-Heck reactions provide convenient and exible access to a diverse range of chiral N-heterocycles. Given the prevalence of stereodened C-N bonds in natural products and pharmaceuticals, the development of enantioselective aza-Heck cyclizations became a key focus of our group. As highlighted above, aza-Heck cyclizations have relatively strict ligand requirements, such that the identication of effective chiral ligands was challenging. Aer extensive investigations, we found that SPINOL-derived P,Nligand (S a ,S)-75 ( Fig. 1)   aza-Heck cyclizations of oxime esters with 1,1-disubstituted alkenes (Scheme 22). 43,44 Presumably, the weakly donating oxazoline moiety is able to mimic the electronic effects of achiral electron-decient triaryl phosphines used earlier (see Scheme 6B).
Using ligand (S a ,S)-75, we found that enantioselective aza-Heck cyclization is efficient with a range of sterically diverse 1,1-disubstituted alkenes, generating targets 24a-f in 68-86% yield and 91 : 9-95 : 5 e.r. (Scheme 22A). Notably, systems with large or small groups at R 2 cyclized with similar levels of efficiency (e.g. 25f, R 2 ¼ Me, 94 : 6 e.r. vs 24f, R 2 ¼ iPr, 93 : 7 e.r.). A stereochemical model that accounts for this observation is outlined in Scheme 22B. The imino group resides trans to the oxazoline and the alkene coordinates cis to this unit. In this arrangement, the alkene favors an orientation where the -CH 2 R 3 substituent is positioned away from the phenyl substituent of the oxazoline. In this model, there are minimal steric interactions between the R 2 substituent and the chiral ligand, which accounts for the similar enantioselectivities observed for 24d, 24e and 24f.
The enantioenriched dihydropyrrole products are suitable for derivatization via either the imine or alkene moieties (Scheme 22C). Exhaustive hydrogenation of 24d provided chiral a-tertiary amine 76 in 97% yield, whereas DIBAL-H reduction of imine 24f generated pyrrolidine 77 with good levels of diastereocontrol. The cyclizations in Scheme 22A are the rst examples of highly enantioselective aza-Heck reactions, adding to a rare yet powerful class of processes that involve enantioselective migratory insertion of alkenes into Pd-N bonds. 4,8,45 The development of further enantioselective aza-Heck cyclizations, including processes that use other N-O donors, is the focus of ongoing efforts.

Conclusions
This perspective summarizes recent progress in the use of aza-Heck cyclizations for the synthesis of chiral nitrogen heterocycles. Building on Narasaka's seminal report, and aided by a detailed interrogation of reaction mechanism, highly efficient cyclizations of oxime esters with cyclic, 1,1-and 1,2-disubstituted alkenes have been developed. Our collective studies have highlighted key ligand requirements and provided a rationalization for the privileged role of pentauorobenzoate leaving groups in such processes. This information guided the design of alkene 1,2-carboamination processes that are initiated by N-O oxidative addition of Pd(0)-catalysts. This fundamental mechanistic step is key to the work described here, and Narasaka's observation of this unusual process heralded the development of a wide range of N-O based processes outside the immediate area of aza-Heck chemistry. Indeed, imino-Pd(II) intermediates now underpin a diverse array of redox-neutral processes including alkene 1,2-carboaminations, 26 aryl C-H aminations, 9 alkene aziridinations, 46 alkene 1,2-iodoaminations, 47 aryne aminofunctionalizations, 38 and C-C bond activations. 25 Exciting recent developments in aza-Heck chemistry have extended N-O oxidative addition to other N-O donors; this is an area that has great potential. Indeed, recent examples of highly enantioselective aza-Heck processes set the stage for the development of a family of redox-neutral enantioselective C-N bond forming processes that are initiated by oxidative addition at electrophilic nitrogen sources.