Synthesis of isophthalates from methyl coumalate

Methyl coumalate reacts with enol ethers to form stable adducts which can be converted into isophthalates in good to excellent yields. Alkyl vinyl ethers afford higher yields of isophthalates than enol silyl ethers. The adduct of the enol silyl ether of acetophenone with methyl coumalate reacted with PTSA to produce a styryl coumalate. Disciplines Environmental Chemistry | Organic Chemistry Comments This article is published as Kraus, George A. and Shuai Wang. "Synthesis of isophthalates from methyl coumalate." RSC Advances 7, no. 89 (2017): 56760-56763. DOI: 10.1039/C7RA12935A. Posted with permission. Creative Commons License This work is licensed under a Creative Commons Attribution 3.0 License. This article is available at Iowa State University Digital Repository: https://lib.dr.iastate.edu/chem_pubs/1069 Synthesis of isophthalates from methyl coumalate† George A. Kraus * and Shuai Wang Methyl coumalate reacts with enol ethers to form stable adducts which can be converted into isophthalates in good to excellent yields. Alkyl vinyl ethers afford higher yields of isophthalates than enol silyl ethers. The adduct of the enol silyl ether of acetophenone withmethyl coumalate reacted with PTSA to produce a styryl

Benzoic acid and isophthalic acid are prepared as commodity chemicals by the benzylic oxidation of toluene or xylene using a cobalt or manganese catalyst. 1Substituted isophthalates are prepared by a variety of methods but benzylic oxidation is a major pathway for 4-phenyl-and 4-methylisophthalic acids. 2 We recently reported the synthesis of para-substituted benzoic acids by the reaction of coumalic acid (generated in one step from malic acid) with alkenes. 3This reaction also proceeds well with methyl coumalate to provide the corresponding esters.The mechanism involves an in situ generated bicyclic lactone which loses carbon dioxide and undergoes dehydrogenation (for X ¼ H) or loses an alcohol (for X ¼ ether), providing the aromatic ester, as illustrated in Scheme 1.
With enol ethers the bicyclic lactone from methyl coumalate can be isolated if the reaction temperature is kept below 100 C. A number of researchers have generated adducts of vinyl ethers with coumalates and have transformed them into substituted cyclohexenes. 4,5Posner and coworkers recently generated complex cyclitols in high yield from an adduct of a pyrone and a vinyl ether. 6Okura and coworkers recently reported cycloadditions using pyrone 3,5-dicarboxylates. 7he ready availability of these bicyclic lactones offered the opportunity to open the lactone under acidic or basic conditions to produce isophthalates.This strategy utilizes all of the carbons of methyl coumalate, increasing the atom economy of the transformation.We report herein that the reaction of the bicyclic lactone intermediates with para-toluenesulfonic acid (PTSA) in boiling methanol afforded very good to excellent yields of the diesters of isophthalic acids.This process is shown below in Scheme 2.
Initially, we studied a number of acids and bases to determine the optimal conditions for isophthalates formation.These results are collated in Table 1.Our best conditions involved ve mole percent of PTSA in boiling methanol.
Examples are illustrated below in Scheme 3. The yields over the two-step sequence are very good.Because methanol is employed as the solvent, the dimethyl esters predominate.
As the results above demonstrate, both cyclic and acyclic vinyl ethers react readily with methyl coumalate.Aromatization Scheme 1 The reaction of methyl coumalate with alkenes.

Scheme 2
The reaction with enol ethers to form isophthalates. with PTSA in methanol gives good yields of isophthalates.In the case of 3a, 15% of the product was the butyl methyl isophthalate.The corresponding enol silyl ethers also formed stable adducts with methyl coumalate; however, the adducts do not undergo high-yield aromatization to afford the isophthalates.As shown below in Scheme 4, the adduct from the reaction of methyl coumalate with the enol silyl ether of cyclopentanone (4) afforded two main products.Apparently, rapid removal of the silyl ether group in methanol yields an alcohol 6 that undergoes some fragmentation in addition to aromatization.Support for this hypothesis is shown in Scheme 5.The adduct of the enol silyl ether of acetophenone reacted with PTSA in methanol to afford a product in 90% yield that was clearly not an isophthalate.Aer examination of the NMR, IR and mass spectrum, we assigned the structure to be pyrone 7 shown in Scheme 5.The mechanism of formation is not clear, but likely involves a retro-aldol reaction and an intramolecular hydride shi followed by loss of water.
Heterocyclic systems also participate effectively in this transformation.Scheme 6 shows the preparation of athiophene substituted isophthalate 9 in very good overall yield.

Conclusions
The two-step Diels-Alder/aromatization pathway to substituted isophthalates proceeds in high overall yields and is operationally convenient.A variety of alkyl, aryl and heteroaryl isophthalates can be prepared.Adducts of alkyl vinyl ethers afford higher yields of isophthalates than adducts of enol silyl ethers.

General procedure for D-A reaction of methyl coumalate with enol ethers
Methyl coumalate (154 mg, 1.0 mmol, 1.0 equiv.),enol ether (3.0 mmol, 3.0 equiv.)and MeCN (1.0 mL) were added to a 15 mL sealed tube.The tube was heated in a 75 C oil bath and stirred for 24 hours.Aer the reaction, the solvent was removed under reduced pressure and the residue was puried by silica gel chromatography.

Table 1
Optimization of the aromatization reaction