Hydrogen-Free Reductive Amination Using Iron Pentacarbonyl as a Reducing Agent

Hydrogen-Free Reductive Amination Using Iron Pentacarbonyl as a Reducing Agent Oleg I. Afanasyev,† Dmitry L. Usanov,‡ Denis Chusov*,†,§ †A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences Vavilova st. 28, Moscow, 119991, Russian Federation ‡c/a: Department of Chemistry and Chemical Biology, Harvard University 12 Oxford Street, Cambridge, MA 02138, USA § Faculty of Science, RUDN University, 6 Miklukho-Maklaya St., Moscow 117198, Russian Federation

Selective and step-economical syntheses of complex molecules from starting materials easily available in bulk quantities are highly important from economic and environmental points of view.Such protocols should naturally tolerate a variety of functional groups, so that extra steps of introduction and removal of protective groups can be avoided.Recently, we have developed a series of methods for hydrogen-free reductive addition using carbon monoxide 1 as a reducing agent. 2 Starting from aldehydes or ketones, this approach can lead to various classes of compounds, including amines, 2b amides, esters, 2e,f pyrrolidines, 2a and nitriles.2f These transformations are usually highly selective and tolerate the presence of aromatic and aliphatic nitrile groups, 2f esters, 2c phenols, 2b carboxybenzyl (Cbz), 2b trifluoroacetamido, 2b N-benzyl, 2a O-benzyl, 2d aromatic fluoro-, 2f chloro-2d and bromo-moieties, 2a cyclopropanes, and even aromatic nitro-groups.2b Selectivities of these reductive aminations usually appreciably exceed those of standard reductive agents, such as sodium cyanoborohydride.2b The natural limitation for the employment of these methods in a laboratory is the necessity to use a carbon monoxide cylinder.
In this context, we sought to develop a homogeneous alternative with CO in a chemically bound form, e.g. using a metal carbonyl complex as a reductant. 3From the points of view of both safety and economy, iron pentacarbonyl seemed to be the best choice since elemental impurities of iron in pharmaceutical products are much less stringently regulated by the corresponding authorities (e.g.FDA) than most other d-metals due to lower intrinsic toxicity of iron. 5Moreover production of iron pentacarbonyl exceeds thousands of tons per year and it is the least expensive metal carbonyl available. 6Iron tetracarbonyl dihydride is a well-known reducing agent; however, it rapidly decomposes at temperatures above −20 °C. 7The sodium salt is more stable, but is not commercially available and requires highly basic conditions for the synthesis, which can lead to a narrower substrate scope. 4Herein, we describe the protocol for reductive amination which employs nothing but starting materials and iron pentacarbonyl.No solvent or external hydrogen source is needed.
We chose morpholine and p-tolylaldehyde as model substrates.In light of the fact that iron pentacarbonyl is a liquid, improvement of the environmental profile of the reaction by the use of solvent-free conditions seemed very interesting.Thus, we heated the reaction components at 90 °C for 4 hours and did detect formation of product 1a (Table 1, entry 1).The temperature influence was found to be important in the range up to 130 °C (Table 1, entries 1-3); at higher temperatures no significant yield variability was found (Table 1, entries 3-6).When the amount of the carbonyl was decreased from three to two equivalents, no significant changes were observed (Table 1, entry 3 vs.8).If the amount of the carbonyl was further decreased, the yield significantly dropped (Table 1, entry 1 vs. 9-11).When the amount of the starting amine (see ESI †) was increased to three equivalents, the yield increased up to 86% with reaction time of four hours.Based on the works of Hieber the reaction between amines and iron pentacarbonyl gives complicated clusters, 8 so the mechanism reductive amination with iron pentacarbonyl seems to be complicated.The molybdenum hexacarbonyl showed the potential in the reductive amination as well (   With these results in hand, we proceeded to investigation of the substrate scope of the developed methodology under the optimized reaction conditions (Fig. 1).
A wide range of aldehydes could be successfully employed, including those containing various functional groups prone to reduction by dihydrogen.For example, benzyloxy moiety (1b), aromatic bromides (1c) and aromatic nitriles (1l) can be tolerated.Aliphatic aldehydes are known to undergo self-aldol reaction catalyzed by amines (especially secondary aliphatic amines); 9 however, under our reaction conditions reductive amination product 1d was isolated in excellent yield.Whereas ketones are usually much less reactive in reductive amination, our methodology worked well with aliphatic ketones 1e-f.Acetophenone could be converted into product 1h with isolated yield of 88%.Moreover, even as unreactive ketone as 2-adamantanone 1g successfully furnished the product in 85% yield.Besides morpholine, other type of tested amines underwent the desired transformation 1i-k in high yields.The optimum reaction temperature was clearly dependent on the nucleophilicity of the starting amine.For pyrrolidine the reaction proceed well even at room temperature (1j, 1l, 1n).Other type of amines also could react at room temperature, albeit with lower rate.We were surprised to found that even benzophenone could be successfully employed: after 12 hours at 90 °C product 1m was isolated in 69% yield.The protocol is so mild that we isolated compound 1n without any side reactions on the styryl moiety.
The scalability and preparative utility of the developed methodology was exemplified on the synthesis of N-adamantylpyrrolidine.Despite the much lower intrinsic reactivity of 2-adamantanone with respect to less sterically challenged substrates, a gram-scale reaction with pyrrolidine proceeded well and furnished product 1n in 89% yield without the need for any chromatographic isolation (Scheme 1).
In conclusion, we have shown that the concept of hydrogenfree reductive amination can be expanded to metal carbonyls as reducing agents, which can lead to the more selective approaches in organic synthesis.The synthetic value of the developed methodology was demonstrated by efficient preparation of a representative range of amines including clean gram-scale synthesis not requiring chromatographic purification.The reaction proceeds well even in case of poorly reactive ketones such as benzophenone.

Table 1
Investigation of the effects of the amount of iron pentacarbonyl and temperature on reductive amination 0.2 mmol scale.1.5 eq. of morpholine were used.b Yields were determined by GC.Tol = p-methylphenyl.c Mo(CO) 6 was used instead of Fe(CO) 5 . a