Metal-free and site-selective α-C–H functionalization of tetrahydrofuran enabled by the photocatalytic generation of bromine radicals

Abstract

The first example of using commercially available and cheap ⁿBu₄NBr as a cocatalyst, which is photoactivated by 4-CzIPN, to selectively activate the α-C–H bond of tetrahydrofuran for C–S and C–C cross-couplings is reported herein. This transition-metal free strategy features operational simplicity, mild and inherent green conditions as well as broad substrate scope.