Issue 8, 2017

Bioapplications of renal-clearable luminescent metal nanoparticles

Abstract

Renal-clearable inorganic nanoparticles (NPs) that hold great potential in the future clinic translations are considered as the next generation of nanomedicine. In the past decade, enormous efforts have been dedicated to the development of renal-clearable NPs with fascinating optical properties, selective disease-targeting capabilities and low nanotoxicities. A further understanding of the design of renal-clearable luminescent metal NPs and their metabolic behavior in the body is important to achieve their clinical transition and extend their bioapplications in disease theranostics. In this review, we discuss the recent synthetic strategies of renal-clearable metal NPs in terms of the considerations of size and composition, surface chemistry and emission wavelength. We also summarize the current disease-related applications of these renal-clearable luminescent metal NPs in tumor targeting, kidney disease and antimicrobial investigations after a discussion of their biological behavior including the pharmacokinetics and biodistribution. Finally, we provide perspectives on the current challenges and upcoming chances for renal-clearable luminescent metal NPs.

Graphical abstract: Bioapplications of renal-clearable luminescent metal nanoparticles

Article information

Article type
Review Article
Submitted
27 Mar 2017
Accepted
18 Apr 2017
First published
18 Apr 2017

Biomater. Sci., 2017,5, 1393-1406

Bioapplications of renal-clearable luminescent metal nanoparticles

L. Gong, Y. Wang and J. Liu, Biomater. Sci., 2017, 5, 1393 DOI: 10.1039/C7BM00257B

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