Immunoaffinity nanogold coupled with direct analysis in real time (DART) mass spectrometry for analytical toxicology

K. M. Evans-Nguyen; T. L. Hargraves; A. N. Quinto

doi:10.1039/C7AY00922D

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Immunoaffinity nanogold coupled with direct analysis in real time (DART) mass spectrometry for analytical toxicology†

K. M. Evans-Nguyen,

*^a T. L. Hargraves^a and A. N. Quinto^a

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* Corresponding authors

^a The University of Tampa, 401 W. Kennedy Blvd., Tampa, FL 33584, USA
E-mail: kevansnguyen@ut.edu

Abstract

A rapid, definitive trace drug identification technique using nanogold surfaces with mass spectrometry was developed. High-surface area nanogold was deposited on gold wires and functionalized with antibodies. Effective drug capture in toxicological matrices with detection using LC-MS/MS and DART-MS/MS was demonstrated.

This article is part of the themed collection: Ambient Mass Spectrometry

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Article information

DOI: https://doi.org/10.1039/C7AY00922D
Article type: Communication
Submitted: 07 Apr 2017
Accepted: 28 May 2017
First published: 30 May 2017

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Anal. Methods, 2017,9, 4954-4957

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Immunoaffinity nanogold coupled with direct analysis in real time (DART) mass spectrometry for analytical toxicology

K. M. Evans-Nguyen, T. L. Hargraves and A. N. Quinto, Anal. Methods, 2017, 9, 4954 DOI: 10.1039/C7AY00922D

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Analytical Methods

Immunoaffinity nanogold coupled with direct analysis in real time (DART) mass spectrometry for analytical toxicology†

Abstract

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Immunoaffinity nanogold coupled with direct analysis in real time (DART) mass spectrometry for analytical toxicology

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