Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

Ji-An Chen; Hongming Pan; Zhijun Wang; Jie Gao; Jiahui Tan; Zhirong Ouyang; Wei Guo; Xianfeng Gu

doi:10.1039/C9CC09158K

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Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission†

Ji-An Chen,^a Hongming Pan,^b Zhijun Wang,^b Jie Gao,^a Jiahui Tan,^a Zhirong Ouyang,^a Wei Guo^b and Xianfeng Gu

*^a

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* Corresponding authors

^a Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201301, China
E-mail: xfgu@fudan.edu.cn

^b Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201301, China

Abstract

We herein develop two β-galactosidase (β-Gal) activatable NIR fluorescent probes for visualizing ovarian cancers. Particularly, probe BOD-M-βGal produced NIR-II emission light at 900–1300 nm upon β-Gal activation. By using our activatable and target specific NIR-II probe for deep-tissue imaging of β-Gal overexpressed ovarian cancer cells, rapid and accurate imaging of ovarian tumors in nude mice was achieved.

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Article information

DOI: https://doi.org/10.1039/C9CC09158K
Article type: Communication
Submitted: 25 Nov 2019
Accepted: 28 Jan 2020
First published: 29 Jan 2020

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Chem. Commun., 2020,56, 2731-2734

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Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

J. Chen, H. Pan, Z. Wang, J. Gao, J. Tan, Z. Ouyang, W. Guo and X. Gu, Chem. Commun., 2020, 56, 2731 DOI: 10.1039/C9CC09158K

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Chemical Communications

Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission†

Abstract

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Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

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