Synthesis of functionalized lactones: catalytic cross-coupling of 1,2-diols and allylic alcohols

Abstract

Simple industrial feedstock chemicals such as allylic alcohols and 1,2-diols are cross-coupled to deliver δ-hydroxybutyrolactones. The reaction occurs through O–H bond activation via amine–amide metal–ligand cooperation involving allylic aldehydes, radical intermediates, and Ru(III) species, as established by EPR studies. This tandem process proceeds with the liberation of molecular hydrogen as the only green byproduct.