Recent advances in asymmetric bimetallic catalysis

Abstract

Asymmetric bimetallic catalysis has emerged as a powerful and efficient approach for the development of novel enantioselective transformations. By employing two metal centers with complementary reactivity, bimetallic catalysts enable dual substrate activation, stabilize reactive intermediates, and facilitate unique transformations with high enantioselectivity. This review summarizes recent significant advances in the field, including three different reaction modes: dual metal Lewis acid catalysis, transition-metal/metal Lewis acid catalysis, and dual transition-metal catalysis. By exploring the latest breakthroughs and providing a comprehensive outlook on the promising potential of asymmetric bimetallic catalysis, we aim to inspire further progress in this rapidly evolving area and highlight future opportunities for expanding its applications.