Nickel-catalyzed reductive cross-coupling of monofluoroalkyl triflates with aryl halides for monofluoroalkylated arenes

Abstract

Here, we report a nickel-catalyzed reductive C(sp³)–C(sp²) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding a series of functionalized monofluoroalkylated arenes. This method is characterized by mild reaction conditions, a broad substrate scope, with excellent functional group compatibility. Facile follow-up transformations highlight its utility as an appealing tool in the synthesis of pharmaceutical derivatives.