Issue 9, 2022

CuCl2·2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes

Abstract

A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of β-acylated enaminones was developed. The cross coupling was accomplished in the presence of CuCl2·2H2O/TBHP and produced the desired β-acylated enaminones in a (Z)-stereo-selective and atom-economic manner, which make this protocol particularly attractive. In the transformation, the new C–C and C–N bonds were formed via a one-pot strategy including the process of radical addition and recombination.

Graphical abstract: CuCl2·2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes

Supplementary files

Article information

Article type
Paper
Submitted
24 Dec 2021
Accepted
04 Feb 2022
First published
07 Feb 2022

Org. Biomol. Chem., 2022,20, 1952-1957

CuCl2·2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes

Y. Zhang, M. Luo, Y. Zhang, K. Cheng, Y. Li, C. Qi, R. Shen and H. Wang, Org. Biomol. Chem., 2022, 20, 1952 DOI: 10.1039/D1OB02479E

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