Issue 109, 2016, Issue in Progress
From the journal:

RSC Advances

Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study†

Richard Cunningham,*a   Nancy C. Forero-Martinez,b   Christopher Hardacre,bc   Tristan G. A. Youngsd  and  Marie E. Migauda  

* Corresponding authors

a School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
E-mail: m.migaud@qub.ac.uk

b School of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK

c School of Chemical Engineering & Analytical Science, The University of Manchester, The Mill (C15), Sackville Street, Manchester M13 9PL, UK

d STFC ISIS Facility, Rutherford Appleton Laboratory, Harwell, Oxford, Didcot, Oxon, OX1 10QX UK

Abstract

Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]−, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.

Graphical abstract: Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

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Article information

DOI
https://doi.org/10.1039/C6RA23078D
Article type
Communication
Submitted
15 Sep 2016
Accepted
03 Nov 2016
First published
04 Nov 2016

RSC Adv., 2016,6, 107214-107218

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Solubility study of tobramycin in room temperature ionic liquids: an experimental and computational based study

R. Cunningham, N. C. Forero-Martinez, C. Hardacre, T. G. A. Youngs and M. E. Migaud, RSC Adv., 2016, 6, 107214 DOI: 10.1039/C6RA23078D

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